| Surf1 | surfeit gene 1 | Surf1 knockdown results in larval lethality. However, knockdown in the central nervous system (CNS) not only bypasses the larval lethality but it results in an increase in maximum lifespan of about 20-30% [16172499]. | Fruit fly |
| sun | Stunted | sun mutations increases lifespan and resistance to oxidative stress [15133470] | Fruit fly |
| spe-26 | Defective SPErmatogenesis | spe-26 mutation in both hermaphrodites and mated males renders them defective in spermatogenesis and increases mean lifespan by about 65%. In hermaprodites spe-26(hc138ts) mutation increases mean and maximum lifespan by 46 and 29%, respectively. Mating does not reduce lifespan in male with spe-26 mutation. Animals with a different spe-26 allele, it118ts, have a similar increase in mean lifespan both in mated males and mated hermaphrodites. Mating even increases spe-26 mutant male lifespan, although the increase is slight (16% increase in mean and 13% increase in maximum lifspan. While compared to wild-type mated spe-26 males have an increase in mean and maximum lifespan of 81 and 63%, respectively, in comparison to wild-type [1448167]. spe-26 loss of function mutation extends lifespan [8807294]. | Nematode |
| Pou1f1 | POU domain, class 1, transcription factor 1 (Pit1, growth hormone factor 1) | Snell dwarf mutation (Pit1dw) due to knockout of Pou1f1 results in a dramatic lifespan extension. The mean, median and maximum lifespan is increased by 40-50% for Snell dwarf (Pit1dw/Pit1dw) DW/J females, and 25-50% for dwarf DWC3F1 males and females with a compound heterozygous Pit1dw/Pit1dw-J genotype. Although, Snell dwarf (Pit1dw/Pit1dw) DW/J males exhibit aspects of delayed senescence, their median lifespan is by about 25% shorter, probably due to the affects of housing conditions [11718806]. Mice homozygous for loss-of-function mutations at Pit1 locus have a mean and maximum lifespan extension over 40%. Mutant dwJ/dw animals exhibit delays in age-dependent collagen cross-linking and in six age-senstive indices of immune system status. Pituitary transplantation into dwarf mice does not reverse the lifespan extension effect. Male Snell dwarf mice become obese and exhibit proportionately high leptin levels in old age [11371619]. | House mouse |
| slcf-1 | SoLute Carrier Family 1 | slcf-1 RNAi or mutation extends the lifespan. slcf-1 mutation increases average lifespan by 40%. DR (by dilution of bacteria on solid medium or by bacterial deprivation) failes to extend slcf-1 mutant's long lifespan and lifespan is even reduced by lowering bacteria concentration (i.e. higher strength of DR) [21040400]. | Nematode |
| SIT4 | Suppressor of Initiation of Transcription 4 | SIT4 deletion slightly increases chronological lifespan and totally abolishes the lifespan shortening due to ISC1 deletion [21707788]. | Budding yeast |
| shk-1 | SHaKer family of potassium channels 1 | shk-1 encodes a shaker family of potassium channel which functions in muscle [21059759], is expressed in sensory neurons [16899454], and downregulated in space. Mutation or RNA interference of shk-1 extends lifespan on NGM agar covered with killed or live bacteria as well as in liquid culture medium. shk-1 RNAi extends mean, 75%ile, and maximum lifespan by 16, 15, and 22%. shk-1(RB1392) mutation extends mean, 75%ile, and maximum lifespan by 19-22, 19-21, and 20-24%. Lifespan extension by unc-17 mutation is totally abolished by RNAi inactivation of either daf-16 or skn-1. eat-2 RNAi shortens the lifespan of shk-1 mutants. RNAi inactivation of shk-1 reduces Q35 aggregation [22768380].
Mutation and RNAi of shk-1 enhance pheromone-induced dauer formation [22768380].
| Nematode |
| daf-28 | Abnormal DAuer Formation | Semi-dominant mutation in daf-28 increases lifespan by 10-15% [8807293]. The daf-28 mutant is dauer constitutive [8005442]. | Nematode |
| sams-1 | S-Adenosyl Methionine Synthetase 1 | sams-1 RNAi significantly extends lifespan of wild-type by 14 - 15%, of daf-16 mutant by 30% and daf-2 by 55%, but fails to significantly further extend lifespan of eat-2 mutants. mRNA level of sams-1 is 2-fold reduced in eat-2 mutants. Like DR, sams-1 RNAi reduces brood size and slightly reproductive timing as well as causes a slender phenotype [16103914]. sams-1 RNAi significantly reduces paralysis in Q35YFP transgenic animals [18331616]. | Nematode |
| RTG3 | ReTroGrade regulation 3 | RTG3 deletion mutation causes an increase in mean replicative in lifespan by 55% increase at 2% glucose, suggesting that expression of genes regulated by Rtg1-Rtg3 has a negative effect on longevity in 2% glucose (in YPK9). A null mutant has 123% increases mean lifespan at 0.1% glucose relative to a wild-type strain at 2% glucose, indicating that reduced glucose and an RTG3 mutation have an additive effect on lifespan (in YPK9) [11024000].
RTG3 null mutant cannot grow on acetate medium and requires glutamate or aspartate for growth [9032238]. | Budding yeast |
| rsr-1 | SR protein related 1 | rsr-1 RNAi in the adulthood extends the mean lifespan by 6% without an effect on maximum lifespan [23144747]. | Nematode |
| rrt-1 | aRginyl aa-tRNA syntheTase | rrt-1 RNAi in the adulthood extends the lifespan [New longevity regulators]. Kockdown of rrt-1 via RNAi started after the animal reached the late L4 stage increases lifespan by 15-27% [22103665]. | Nematode |
| RPS6B | — | RPS6B deletion increases mean replicative lifespan by about 30% [16293764]. Deletion of RPS6B, but not of the RPS6A paralog increases replicative median lifespan robustly by 45% [17174052]. | Budding yeast |
| rps-14 | Ribosomal Protein, Small subunit | rps-14 RNAi in the adulthood extends mean and maximum lifespan by 17 and 22% [23144747]. Knockdown of rps-14 via RNAi started after the animal reached the late L4 stage extends lifespan by 6-19% [22103665]. | Nematode |
| rps-12 | Ribosomal Protein, Small subunit | rps-12 RNAi in the adulthood extends mean and maximum lifespan by 12 and 22%, respectively [23144747]. | Nematode |
| rpb-8 | RNA Polymerase II (B) subunit 8 | rpb-8 RNAi in the adulthood extends the mean lifespan by 6% without any apparent effect on maximum lifespan [23144747]. | Nematode |
| rpa-1 | Replication Protein A homolog 1 | rpa-1 RNAi in the adulthood extends the mean and maximum lifespan by 5 and 22%, respectively [23144747]. | Nematode |
| rnr-2 | RiboNucleotide Reductase | rnr-2 RNAi in the adulthood extends mean and maximum lifespan by 14 and 22%, respectively [23144747]. | Nematode |
| ubh-4 | UBiquitin C-terminal Hydrolase (family 1) | RNAi of ubh-4 starting at L1 extends mean, 25%ile and median lifespan by 3, 8 and 8% [15998808]. | Nematode |
| spt-4 | SPT transcription factor family | RNAi of spt-4 starting at L1 extends mean, 75%ile and median lifespan by 4, 8 and 8% [15998808]. | Nematode |
| rnf-5 | RiNg Finger protein | RNAi of rnf-5 starting at L1 extends mean, 25%ile and median lifespan by 3, 8 and 8% [15998808]. | Nematode |
| mecr-1 | — | RNAi of mecr-1 extends mean, median and 25%ile lifespan by 6, 8 and 8% [15998808]. | Nematode |
| mak-2 | MAP kinase Activated protein Kinase | RNAi of mak-2 increases mean and maximum lifespan by 12 and 14% [19293945]. | Nematode |
| inx-14 | INneXin | RNAi of inx-14 starting at L1 increases mean, 25%ile and median lifespan by 6, 8 and 14% [15998808]. | Nematode |
| gcy-18 | Guanylyl CYclase 18 | RNAi of gcy-18 increases mean lifespan by 25%. gcy-18 expression is repressed by daf-2 RNAi, but induced by combined RNAi of daf-16 and daf-2 [12845331]. | Nematode |
