| VEGFA | vascular endothelial growth factor A | VEGFA was found to be associated with longevity [17574707]. VEGFA was not found to be associated with longevity [17574707]. | Human |
| VDR | vitamin D (1,25- dihydroxyvitamin D3) receptor | VDR was found to be associated with longevity [21051524]. VDR was not found to be associated with longevity [20407924]. VDR was found to be associated with longevity [20407924]. | Human |
| TSHR | thyroid stimulating hormone receptor | Two single nucleotide in the TSHR were associated with increased TSH in both centenarians and their offspring [19837933].TSHR was found to be associated with longevity [19837933]. TSHR was not found to be associated with longevity [19837933]. | Human |
| APOA4 | apolipoprotein A-IV | Two restriction polymorphisms, HinfI347 (Thr347/Ser) and Fnu4HI360 (Gln360/His), and a VNTR (alleles 3, 4) at the 3 region of the APOA4 gene were examined in 71 centenarians (18 men and 53 women, 100-107 years of age, mean 102.3 years) and 100 unrelated adults (21 men and 79 women, 19-59 years of age, mean 35.7 years). The Hinf347 genotype distribution was significantly different in centenarians [9622284].APOA4 was found to be associated with longevity [9533408]. APOA4 was found to be associated with longevity [9622284]. APOA4 was not found to be associated with longevity [9622284]. APOA4 was not found to be associated with longevity [12556235]. | Human |
| TSPAN32 | tetraspanin 32 | TSPAN32 was found to be associated with longevity [19367319]. TSPAN32 was not found to be associated with longevity [19367319]. | Human |
| SNCA | synuclein, alpha (non A4 component of amyloid precursor) | Transgenic lines overexpressing either human wild-type or mutant (A53T) forms of the SNCA (alpha-synclein) gene under a pan-neuronal promoter live on average about 25% longer, even in weak (m577) and strong (e1370) daf-2 mutant backgrounds, and exhibited decreased pharyngeal pumping and egg-laying. Wild-type SNCA crossed into eat-2(ad1113) does not significantly effect lifespan compared to that of the background strain. Pumping rate in wild-type SCNA and A53T SCNA overexpression mutants were less than control already at day 1 of adulthood. The attenuation of lifespan exptesion by SNCA overexpression by growing on thick bacterial lawns, suggests that DR may explain some fo the effects on lifespan. SCNA overexpression increases average lifespan by 21.3% (wild-type) and 16.3% (A53T) [16782295].
Mutation of SCNA (alias alpha synclein) is associated with Parkinson's disease [9197268], which is characterized with resting tremor, rigidity bradykinesia and posural instability that are associated with selective neurodegeneration of the pigmented neurons in the brain stem (substantia nigra and locus coerues) and the presence of intracytoplasmic inclusion bodies (Lewy bodies) [Yamamura et al. 1973]. The mutated protein (Ala53Thr or Ala30Pro) may misfold, aggregate and resist degradation [11433374].SNCA was found to be associated with longevity [22912757]. SNCA was not found to be associated with longevity [22912757]. | Human |
| TOMM40 | translocase of outer mitochondrial membrane 40 homolog (yeast) | TOMM440 correlates substantial with longevity and has been associated with Alzheimer's disease [22279548].
rs4420638 at TOMM40 gene locus exhibits significant association with longevity p-value = 9.6x10^-8). Combined modeling of linkage and association shows that association of longevity with APOEepsilon4 and APOEepsilon2 alleles explain the linkage at 19q1.11-q13.32 with pvalue-0.02 and p-value=1.0x10^-5, respectively [23286790]. TOMM40 was found to be associated with longevity [21418511; 23040522; 22279548]. TOMM40 was not found to be associated with longevity [24924924]. TOMM40 was found to be associated with longevity [24924924]. | Human |
| TNFa | tumor necrosis factor | TNFa was found to be associated with longevity [17989723]. TNFA was not found to be associated with longevity [21865054]. | Human |
| SOD2 | superoxide dismutase 2, mitochondrial | The SOD2 rs2758331 has been correlated with exceptional longevity in a plethora of genetic signatures [22279548].SOD2 was found to be associated with longevity [20003469]. SOD2 was found to be associated with longevity [17903295]. SOD2 was found to be associated with longevity [15621215]. SOD2 was found to be associated with longevity [20003469]. SOD2 was found to be associated with longevity [19428448]. SOD2 was not found to be associated with longevity [9887369]. SOD2 was found to be associated with longevity [22279548]. SOD2 was not found to be associated with longevity [24163049]. | Human |
| EXO1 | exonuclease 1 | The rs1776180 C allele in the promoter of EXO1 is significantly enriched in female Germans centenarians and this can be replicated in 445 female French centenarians. The C allele leads to the loss of binding site for the basic helix-loop-helix transcription factor E47, resulting in higher EXO1 expression [19698732].EXO1 was found to be associated with longevity [19698732]. EXO1 was not found to be associated with longevity [23770741]. | Human |
| KL | klotho | The KL-VS allele of the klotho gene is more common in infants than in elderly individuals. Individuals homozygous for KL-VS have a 2.6-fold greater chance of dying by age 65 than individuals that are homozyogous that are homozyogous for the wild-type klotho allele [11792841]. KL was found to be associated with longevity [17903295; 22406557; 15677572]. KL was not found to be associated with longevity [18034366]. KL was found to be associated with longevity [24164579]. | Human |
| ACE | angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 | The I/D polymorphism in ACE was a examined in centenarians (n = 338) and in adults aged 20-70 years. A variant of ACE which predisposes the coronary heat disease was more frequently in centenarians with a significant increase of the homozygous genotype [8136829].
I/D polymorphism was examined in 182 women and 100 men aged >84 years and in 100 boys and 100 girls younger than 17 years. The I/I polymorphism was depleted in the elderly males but not in the elderly females. Furthermore, significant differences were observed between ACE genotypes in elderly men and elderly women [9105559].
I/D polymorphism was examined in 394 French centenarians (13% men and 87% women) and controls (238) from 20 to 70 years of age (140 men and 98 women). Both the ACE D allele and ACE D/D genotype were more frequent in centenarians in comparison with controls, without sex-related differences nor significant correlation with a cardiovascular pathology [9761238].
I/D polymorphism was examined in 424 subjects comprising 227 Uighur individuals, 108 Kazakh individuals, and 89 Han individuals. All subjects in the latter two groups ranged in age from 65 to 70 years, whereas the Uighur subjects comprised two different age groups: those ranging in age from 59 to 70 years and those ranging in age from 90 to 113 years. Within the Uighur group, frequency of the D allele was significantly higher in the group aged >90 than in the group aged <70. The overall distributions of alleles in the three groups did not differ significantly [11773214].
Alleles of ACE was found to be associated with longevity [12547486; 22456784].ACE was found to be associated with longevity [11773214]. ACE was found to be associated with longevity [16960022]. ACE was found to be associated with longevity [19502260]. ACE was found to be associated with longevity [12634288]. ACE was found to be associated with longevity [23389097]. ACE was found to be associated with longevity [12547486]. ACE was found to be associated with longevity [22456784]. ACE was found to be associated with longevity [14528043]. ACE was found to be associated with longevity [8136829]. ACE was found to be associated with longevity [21614448]. ACE was found to be associated with longevity [21330423]. ACE was found to be associated with longevity [19502260]. ACE was found to be associated with longevity [9105559]. ACE was found to be associated with longevity [9761238]. ACE was not found to be associated with longevity [11280044]. ACE was not found to be associated with longevity [14528043]. ACE was not found to be associated with longevity [21330423]. ACE was not found to be associated with longevity [9761238]. ACE was found to be associated with longevity [23623925]. | Human |
| TNF | tumor necrosis factor | The frequency of the -308 polymorphism in the TNF gene was analyzed in 71 healthy elders, aged 80 to 96 years (mean 86.2 years). The control samples were obtained from 99 young (from 21 - 54 years; mean 35.2 years) healthy individuals unrelated to elders were studied, age ranged from 80 to 96 years (mean 86.2 years). The TNF2 allele was increased in the elder group when compared to young controls [16269080].TNF was found to be associated with longevity [20518833]. TNF was found to be associated with longevity [18511747]. TNF was found to be associated with longevity [12714268]. TNF was found to be associated with longevity [12714268]. TNF was found to be associated with longevity [12676903]. TNF was found to be associated with longevity [11640949]. TNF was found to be associated with longevity [21299522]. TNF was found to be associated with longevity [21299522]. TNF was not found to be associated with longevity [12676903]. TNF was found to be associated with longevity [16269080]. TNF was not found to be associated with longevity [11640949]. | Human |
| IFNG | interferon, gamma | The distribution of 874T/A polymorphism in the IFNG gene was examined in 174 Italian centenarians (>99 years old, 142 women and 32 men) and 248 <60-year-old control subjects (90 women and 158 men). The +874T allele, known to be associated with low IFN-gamma production, was found less frequently in centenarian women than in centenarian men or in control women whereas no significant differences were observed in the distribution of the two alleles between male or female controls. Allele frequencies in centenarian men were not found significantly different from male controls [11772518].IFNG was found to be associated with longevity [21299522]. IFNG was not found to be associated with longevity [11772518]. IFNG was found to be associated with longevity [11772518]. | Human |
| TLR4 | toll-like receptor 4 | The ASP299GLY ploymorphism in the TLR4 gene shows a significantly lower frequency in patients affected by myocardial infarction compared to controls, whereas centenarians exhibit a higher frequency [16803999]. TLR4 was found to be associated with longevity [16803999; 17493663].TLR4 was found to be associated with longevity [17493663]. TLR4 was not found to be associated with longevity [17493663]. | Human |
| IL10 | interleukin 10 | The -1082G/A, -819C/T and -592C/A proximal promoter SNPs of the IL10 gene were examined in 190 centenarians (>99 years old, 159 women and 31 men) and in 260 control subjects (99 women and 161 men less than 60 years old). The -1082G homozygous genotype, associated with high IL-10 production, was increased in centenarian men but not in centenarian women. No difference was found between centenarians and control subjects regarding the other two SNPs [11857058].IL10 was found to be associated with longevity [20518833]. IL10 was found to be associated with longevity [12676903]. IL10 was found to be associated with longevity [12676903]. IL10 was found to be associated with longevity [11640949]. IL10 was found to be associated with longevity [21299522]. IL10 was found to be associated with longevity [21299522]. IL10 was found to be associated with longevity [11857058]. IL10 was found to be associated with longevity [15466015]. IL10 was not found to be associated with longevity [11640949]. | Human |
| TH | tyrosine hydroxylase | TH was not found to be associated with longevity [12297342]. TH was found to be associated with longevity [12297342]. | Human |
| TERT | telomerase reverse transcriptase | Telomerase-expressing cells (human foreskin fibroblasts, retinal pigment epithelial cells) maintain normal length of telomeres and continue to divide vigorously [9454332]. Cells expression telomerase have reduced staining for beta-galactosidase (a biomarker of cellular senescence) [9501072]. TERT expression is also able to prevent the accelerated replicative senescence observed in cells taken from Werner's patients [10615119].
A haplotype of TERT was correlated with both longer both longer telomere length and exceptional longevity. Mutations in TERT were overpresented in Ashkenazi centenarians [19915151].TERT was not found to be associated with longevity [22136229]. TERT was found to be associated with longevity [23562826]. | Human |
| SUMF1 | sulfatase modifying factor 1 | SUMF1 was found to be associated with longevity [22279548]. SUMF1 was not found to be associated with longevity [21612516]. | Human |
| SORCS1 | sortilin-related VPS10 domain containing receptor 1 | SORCS1 was found to be associated with longevity [22279548]. SORCS1 was not found to be associated with longevity [21612516]. SORCS1 was found to be associated with longevity [24244950]. | Human |
| SIRT3 | sirtuin 3 | SIRT3 was found to be associated with longevity [14580859]. SIRT3 was found to be associated with longevity [15676284]. SIRT3 was found to be associated with longevity [15676284]. SIRT3 was found to be associated with longevity [19367319]. SIRT3 was found to be associated with longevity [19367319]. SIRT3 was not found to be associated with longevity [19367319]. SIRT3 was found to be associated with longevity [17989723]. SIRT3 was not found to be associated with longevity [23839864]. SIRT3 was found to be associated with longevity [23839864]. | Human |
| SIRT1 | sirtuin 1 | SIRT1 was found to be associated with longevity [21972126; 16257164; 16257164; 16257164; 16257164; 16257164; 21972126; 20633545]. SIRT1 was not found to be associated with longevity [16257164; 18765803].SIRT1 was found to be associated with longevity [23505545]. SIRT1 was found to be associated with longevity [23450480]. SIRT1 was not found to be associated with longevity [23450480]. | Human |
| SHC1 | SHC (Src homology 2 domain containing) transforming protein 1 | SHC1 was found to be associated with longevity [15036421]. SHC1 was found to be associated with longevity [15036421]. SHC1 was found to be associated with longevity [15036421]. SHC1 was found to be associated with longevity [15036421]. SHC1 was found to be associated with longevity [14530863]. SHC1 was found to be associated with longevity [14530863]. SHC1 was found to be associated with longevity [14530863]. SHC1 was found to be associated with longevity [14530863]. SHC1 was not found to be associated with longevity [19489743]. | Human |
| RANTES | ATP synthase, H+ transporting, mitochondrial Fo complex, subunit G | RANTES was not found to be associated with longevity [22265023]. RANTES was found to be associated with longevity [22265023]. | Human |
| PVRL2 | — | PVRL2 was found to be associated with longevity [24924924]. PVRL2 was not found to be associated with longevity [24924924]. | Human |
