| ucr-1 | Ubiquinol-Cytochrome c oxidoReductase complex | RNAi against ucr-1 increases mean lifespan by 20% [17608836]. ucr-1 RNAi started after the animal reached the late L4 stage increase mean lifespan by 8-14% [22103665]. | Nematode |
| ttll-9 | Tubulin Tyrosine Ligase Like | Knockdown of ttll-9 throughout the entire life increases the lifespan by 3% [23698443]. | Nematode |
| tub-1 | TUBby-related | Mutation of tub-1 (alleles nr2004 and nr2044) leads to 20-25% life-extension dependent on daf-16 [16054097].
tub-1 mutation promotes increased fat accumulation [16054097]. | Nematode |
| C47D12.2 | TRRAP-like (transcription/transformation domain-associated protein) | C47D12.2 RNAi in the adulthood extends mean and maximum lifespan by 6 and 9% [23144747]. | Nematode |
| TRM9 | TRna Methyltransferase 9 | TRM9 deletion almost triples mean chronological lifespan under starvation/extreme DR, increases heat resistance, but reduces resistance to acetic acid. Similar effect were present in the BY746 background in SDC medium [20657825]. | Budding yeast |
| trim-9 | TRIpartite Motif-containing protein homolog 9 | RNA interference of trim-9 extends lifespan [15998808]. | Nematode |
| TPS3 | Trehalose-6-Phosphate Synthase 3 | Deletion of TPS3 extend the mean chronological lifespan by 39% (at 30 degree Celsus in BY4742) [22783207].
TPS3 mutants have higher trehalose levels until the end of the post-diauxic growth phase, but reaches a plateau at the level of 50-70% of wild-type in the stationary phase [22783207]. | Budding yeast |
| TSL1 | Trehalose Synthase Long chain 1 | Deletion of TSL1 extends the mean chronological lifespan by 43% (at 30 degree Celsus in BY4742) [22783207].
Mutant TSL1 cells have reduced oxidative carbonylation of cellular proteins throughout lifespan. TSL1 mutants have higher trehalose levels, but reaches a plateau at the level of 50-70% of wild-type in the stationary phase. TSL1 deletion cells have no altered ROS levels in pre-quiescent cells [22783207]. | Budding yeast |
| C09B7.2 | transposase | RNA interference of C09B7.2 extends lifespan [15998808]. | Nematode |
| TMA19 | Translation Machinery Associated 19 | Deletion of TMA19 increases replicative lifespan by 16% (P<0.02) [16806052]. TMA19 deletion increases replicative lifespan by 25-30% in the alpha and a strains [19030232].
| Budding yeast |
| TIF4631 | Translation Initiation Factor 4631 | Deletion of TIF4631 increases replicative lifespan by 20% in the alpha and a strains [18340043].
TIF4631 increases replicative lifespan by 10-20% in the alpha and a strains [19030232]. | Budding yeast |
| TIF1 | Translation Initiation Factor 1 | Deletion of TIF1 increases replicative lifespan by 20% in the alpha strain [19030232]. TIF1 deletion increases by 30% in the alpha strain and 15% in the a strain [18340043].
| Budding yeast |
| Trp53 | Transformation related protein 53 | Mice heterozyogous for an allele of p53 that removes the 5' portion of the protein demonstrate decreased cancer, permature aging phenotypes, and shortened lifespan in the mixed inbred C57BL/6â129/Sv background. It has been proposed that the this allele of p53 results in increased activity/overexpression [11780111]. Decreased activity of Trp53 results in increased cancer and decreased apoptosis. Mutant mice with activated Trp53 display enhanced resistance to spontaneous tumours and signs of premature ageing including reduced lifespan, osteoporosis, organ atrophy and a diminished stress tolerance [11780111]. However, super-p53 mice generate by a transgenic copy of a large genomic segment containing an intact and complete copy of p53 have an ehanced response to DNA damage, are significantly protected from cancer and had no indication of accelerated aging [12426394]. super-Ink4a/Arf/p53 mice have a synergic protection against cancer and delayed aging [Workshop RoSyBa 2011]. | House mouse |
| GCN4 | Transcriptional activator of amino acid biosynthetic genes in response to amino acid starvation; expression is tightly regulated at both the transcriptional and translational levels | Deletion of GCN4 increases the replicative lifespan by 10% in the alpha strain [19030232].
GCN4 deletion decreases the lifespan in the alpha and a strain [20657825].
The chronological lifespan of GCN4 deletion is strongly decreased in the a strain [20421943]. | Budding yeast |
| TCO89 | Tor Complex One | TCO89 deletion increases chronological lifespan, increases mitochondrial oxygen consumption, but decreases mitochondrial and cellular ROS in early stationary phase [21641548]. Deletion of TCO89 cancels out replicative lifespan extension by moderate DR [18690010]. | Budding yeast |
| tag-322 | Temporarily Assigned Gene name | tag-322 RNAi increases mean and maximum lifespan by 18 and 12%, respectively [19293945]. | Nematode |
| Terf2 | telomeric repeat binding factor 2 | Overexpression results in signs of premature ageing. | House mouse |
| TOS8 | Target Of Sbf 8 | Deletion of TOS8 increases replicative lifespan increased by 35% in the alpha strain [18340043]. | Budding yeast |
| TOR1 | Target Of Rapamycin 1 | TOR1 deletion extends mean and maximum replicative lifespan by 21 and 25% [16293764] as well as chronological lifespan [21076178]. This lifespan extension is independent of SIR2 and additive with deletion of FOB1 [16293764]. Deletion of TOR1 fails to increase the replicative lifespan of a sir2 mutant [20947565]. Deletion of TOR1 substantially extends chronological lifespan, increasing median survival almost 3-fold (wild-type 4.5 days, tor1 null 12 days), i.e. by 167%. By 21 days in culture, the vast majority of wild-type cells had died (>99.9%), whereas many tor1 null cells remained viable. Deletion of TOR1 also extends the chronological lifespan of the relatively short-lived BY4742 strain, one of the two haploid genetic backgrounds of the widely used Yeast Knockout Collection available from Open Biosystems. Deletion of TOR1 fails to extend chronological lifespan in Petite strains that are unable to respire [17403371]. TOR1 deletion increases replicative lifespan by 30% in the alpha strain and 20% in a strain [19030232]. TOR1 deletion mutant have and increased mean and maximum replicative lifespan by 21% and 6%, respectively [21931558]. Deletion of TOR1 extends replicative lifespan as well as chronological lifespan [21076178] and glucose restriction fails to further extend the long replicative lifespan of tor1Delta [16293764; 16418483; 18225956]. Water starvation (extreme DR) further extends chronological lifespan of tor1 mutants [18225956]. | Budding yeast |
| Tor | Target of rapamycin | Expression of a dominant-negative form of Tor extends lifespan [15186745]. Ubiquitious overexpression of dTOR with the da-GAL4 driver of UAS-dTOR(FRB) which contains the 11kDA FKB12-rapamycin binding domain led to a mean and maximum lifespan increase of 15% (24%) and 29% at 29°C and of 50% (26%) and 13% at 25°C, respectively [15186745].
Overexpression of the dominant-negative form of Tor specifically in the fat and muscle tissues is sufficient to extend the mean and maximum lifespan by 24 and 19%, respectively [15186745].
Overexpression of UAS-dTOR(WT) or UAS-dTOR(TED) prevents eclosion to adulthood [15186745]. | Fruit fly |
| tdp-1 | TAR DNA-binding Protein homolog 1 | tdp-1(ok803) mutation increases mean and maximum lifespan at 20 degree Celsius but not at 25 degree Celsius. tdp-1(ok803) reduce the lifespan of daf-2(e1370) mutants, but does not does not reduces the lifespan of daf-16(mu86) mutants. RNAi against tdp-1 reduces lifepsna of daf-2(e1370) mutants. tdp-1 overexpression strains have a reduced lifespan at 20 and 25 degree Celsius [Vaccaro et al. 2012]. | Nematode |
| sid-2 | Systemic RNA Interference Defective 2 | RNA interference of sid-2 extends lifespan [15998808]. | Nematode |
| SLM6 | Synthetic Lethal with Mss4 6 | Deletion of SLM6 increases replicative lifespan by approximately 37% in BY4742 [16293764] as well as mean chronological lifespan 13 - 210% (13, 49, 52, 210) in diploid cells [21447998].
SLM6 is a dubious ORF overlapping with REI1. | Budding yeast |
| Surf1 | surfeit gene 1 | Knockout mice displayed a prolonged lifespan of about 20%. | House mouse |
| Surf1 | surfeit gene 1 | Surf1 knockdown results in larval lethality. However, knockdown in the central nervous system (CNS) not only bypasses the larval lethality but it results in an increase in maximum lifespan of about 20-30% [16172499]. | Fruit fly |
