| ATK1 | v-akt murine thymoma viral oncogene homolog 1 | ATK1 was found to be associated with longevity [21418511]. | Human |
| UCK2 | uridine-cytidine kinase 2 | UCK2 was found to be associated with longevity [22445811]. | Human |
| Ucp3 | uncoupling protein 3 (mitochondrial, proton carrier) | Metabolic intensity (daily food energy/body mass) correlates with longevity in MF1 mice. The animals with the highest quartile of metabolic intensities have a mean lifespan of 36% longer than animals with the lowest quartile of metabolic intensities. The highest metabolism of long-lived animals can be attributed to increased uncoupling Ucp3 [15153176].
Skeletal muscle mitochondria isolated from high metabolism mice are more uncoupled that those from low metabolism mice [15153176]. | House mouse |
| UCP3 | uncoupling protein 3 (mitochondrial, proton carrier) | UCP3 was found to be associated with longevity [22743239]. UCP3 was found to be associated with longevity [22743239]. UCP3 was found to be associated with longevity [22743239]. UCP3 was found to be associated with longevity [22743239]. UCP3 was found to be associated with longevity [22743239]. UCP3 was found to be associated with longevity [22743239]. | Human |
| UCP1 | uncoupling protein 1 (mitochondrial, proton carrier) | UCP1 was found to be associated with longevity [21827845]. | Human |
| GALNTL2 | UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 2 | GALNTL2 was found to be associated with longevity [21782286]. | Human |
| UBE2H | ubiquitin-conjugating enzyme E2H (UBC8 homolog, yeast) | UBE2H was found to be associated with longevity [22279548]. | Human |
| Ubash3b | ubiquitin-associated and SH3 domain-containing protein B | Ubash3b is transcriptional downregulated in the cerebral cortex at the age 28 months under different longevity conditions such as under dietary restriction (DR) as well as in feeding switch regimens that result in extended lifespan, like early age switch to DR as well as the reverse switch under the influence of the DR-mimetic α-lipoic acid (i.e. DR switched to ad libitum+ lipoic acid) [Shona et al. 2013]. | Norway rat |
| U4 | U4 spliceosomal RNA | U4 is transcriptional upregulated in the cerebral cortex at the age 28 months under different longevity conditions such as under dietary restriction (DR) as well as in feeding switch regimens that result in extended lifespan, like early age switch to DR as well as the reverse switch under the influence of the DR-mimetic α-lipoic acid (i.e. DR switched to ad libitum+ lipoic acid) [Shona et al. 2013]. | Norway rat |
| TH | tyrosine hydroxylase | Polymorphyc repeats in intron 1 (Short and Long alleles) of the TH gene were examined in 196 centenarians (143 females and 53 males) and 358 controls (196 females and 162 male; 10-85 years old). A significant loss of LL homozygous genotypes was found at the THO locus in male but not in female centenarians with respect to matched controls [9887369].TH was found to be associated with longevity [12297342]. TH was found to be associated with longevity [21407269]. TH was found to be associated with longevity [19367319]. TH was not found to be associated with longevity [19367319]. TH was found to be associated with longevity [11053670]. TH was found to be associated with longevity [17989723]. | Human |
| TH | tyrosine hydroxylase | TH was not found to be associated with longevity [12297342]. TH was found to be associated with longevity [12297342]. | Human |
| TUSC3 | tumor suppressor candidate 3 | TUSC3 was found to be associated with longevity [22279548]. | Human |
| p53 | tumor protein p53 | p53 was found to be associated with longevity [10577935]. | Human |
| NFkB | tumor necrosis factor receptor superfamily, member 11a, NFKB activator | NFkB was found to be associated with longevity [23389097]. | Human |
| TNFRSF11A | tumor necrosis factor receptor superfamily, member 11a, NFKB activator | TNFRSF11A was found to be associated with longevity [22279548]. | Human |
| TNFSF8 | tumor necrosis factor (ligand) superfamily, member 8 | TNFSF8 was found to be associated with longevity [22279548]. | Human |
| TNF | tumor necrosis factor | The frequency of the -308 polymorphism in the TNF gene was analyzed in 71 healthy elders, aged 80 to 96 years (mean 86.2 years). The control samples were obtained from 99 young (from 21 - 54 years; mean 35.2 years) healthy individuals unrelated to elders were studied, age ranged from 80 to 96 years (mean 86.2 years). The TNF2 allele was increased in the elder group when compared to young controls [16269080].TNF was found to be associated with longevity [20518833]. TNF was found to be associated with longevity [18511747]. TNF was found to be associated with longevity [12714268]. TNF was found to be associated with longevity [12714268]. TNF was found to be associated with longevity [12676903]. TNF was found to be associated with longevity [11640949]. TNF was found to be associated with longevity [21299522]. TNF was found to be associated with longevity [21299522]. TNF was not found to be associated with longevity [12676903]. TNF was found to be associated with longevity [16269080]. TNF was not found to be associated with longevity [11640949]. | Human |
| TNFa | tumor necrosis factor | TNFa was found to be associated with longevity [17989723]. TNFA was not found to be associated with longevity [21865054]. | Human |
| TNFb | tumor necrosis factor | TNFb was found to be associated with longevity [17989723]. | Human |
| TUBB4B | tubulin, beta 2C | TUBB4B was found to be associated with longevity [22174011]. | Human |
| TRIM25 | tripartite motif containing 25 | TRIM25 was found to be associated with longevity [22279548]. | Human |
| Tmem218 | Transmembrane protein 218 | Tmem218 is transcriptional upregulated in the cerebral cortex at the age 28 months under different longevity conditions such as under dietary restriction (DR) as well as in feeding switch regimens that result in extended lifespan, like early age switch to DR as well as the reverse switch under the influence of the DR-mimetic α-lipoic acid (i.e. DR switched to ad libitum+ lipoic acid) [Shona et al. 2013]. | Norway rat |
| TMEM2 | transmembrane protein 2 | TMEM2 was found to be associated with longevity [22279548]. | Human |
| TOMM40 | translocase of outer mitochondrial membrane 40 homolog (yeast) | TOMM440 correlates substantial with longevity and has been associated with Alzheimer's disease [22279548].
rs4420638 at TOMM40 gene locus exhibits significant association with longevity p-value = 9.6x10^-8). Combined modeling of linkage and association shows that association of longevity with APOEepsilon4 and APOEepsilon2 alleles explain the linkage at 19q1.11-q13.32 with pvalue-0.02 and p-value=1.0x10^-5, respectively [23286790]. TOMM40 was found to be associated with longevity [21418511; 23040522; 22279548]. TOMM40 was not found to be associated with longevity [24924924]. TOMM40 was found to be associated with longevity [24924924]. | Human |
| TGFB1 | transforming growth factor, beta receptor 1 | TGFB1 was found to be associated with longevity [15569360]. | Human |
