| wah-1 | Worm AIF (apoptosis inducing factor) Homolog | wah-1 RNAi in the adulthood extends the lifespan [New longevity regulators]. RNAi against wah-1 started after the animal reaches the late L4 stage extends mean lifespan by 7-8% [22103665]. | Nematode |
| rps-14 | Ribosomal Protein, Small subunit | rps-14 RNAi in the adulthood extends mean and maximum lifespan by 17 and 22% [23144747]. Knockdown of rps-14 via RNAi started after the animal reached the late L4 stage extends lifespan by 6-19% [22103665]. | Nematode |
| hmg-4 | HMG 4 | hmg-4 RNAi in the adulthood extends mean lifespan by 7%, without an effect on maximum lifespan [23144747]. | Nematode |
| C47D12.2 | TRRAP-like (transcription/transformation domain-associated protein) | C47D12.2 RNAi in the adulthood extends mean and maximum lifespan by 6 and 9% [23144747]. | Nematode |
| rrt-1 | aRginyl aa-tRNA syntheTase | rrt-1 RNAi in the adulthood extends the lifespan [New longevity regulators]. Kockdown of rrt-1 via RNAi started after the animal reached the late L4 stage increases lifespan by 15-27% [22103665]. | Nematode |
| rnr-2 | RiboNucleotide Reductase | rnr-2 RNAi in the adulthood extends mean and maximum lifespan by 14 and 22%, respectively [23144747]. | Nematode |
| mel-28 | Maternal Effect Lethal 28 | mel-28 RNAi in the adulthood extends mean and maximum lifespan by 7 and 9%, respectively [23144747]. | Nematode |
| lin-5 | abnormal cell LINeage | lin-5 RNAi in the adulthood extends mean and maximum lifespan by 16 and 9% [23144747]. | Nematode |
| emb-27 | abnormal EMBroygenesis 27 | emb-27 RNAi in the adulthood extends mean and maximum lifespan by 11 and 9%, respectively [23144747]. | Nematode |
| aps-1 | AdaPtin, Small chain (clathrin associated complex) 1 | aps-1 RNAi in the adulthood extends mean lifespan by 8% without any apparent effect on maximum lifespan [23144747]. | Nematode |
| F09F7.4 | NEK (NEver in mitosis Kinase) Like | F09F7.4 RNAi in the adulthood extends the lifespan [New longevity regulators]. RNAi against F09F7.4 started after the animal reached the late L4 stage increases mean lifespan by 6-12% [22103665]. | Nematode |
| rsr-1 | SR protein related 1 | rsr-1 RNAi in the adulthood extends the mean lifespan by 6% without an effect on maximum lifespan [23144747]. | Nematode |
| nhr-23 | Nuclear Hormone Receptor family 23 | nhr-23 RNAi in the adulthood extends mean and maximum lifespan by 5 and 9%, respectively [23144747]. | Nematode |
| gpd-3 | GPD (glyceraldehyde 3-phosphate dehydrogenase) 3 | gpd-3 RNAi in the adulthood extends the mean lifespan by 5% without a change in maximum lifespan [23144747]. | Nematode |
| fkb-6 | FK506-Binding protein family 6 | fkb-6 RNAi in the adulthood extends the mean lifespan by 2.9% [New longevity regulators]. | Nematode |
| chn-1 | C-term of Hsp70-iNteracting protein (CHIP family) 1 | chn-1 RNAi in the adulthood extends mean and maximum lifespan by 7 and 9%, respectively [23144747]. | Nematode |
| rpb-8 | RNA Polymerase II (B) subunit 8 | rpb-8 RNAi in the adulthood extends the mean lifespan by 6% without any apparent effect on maximum lifespan [23144747]. | Nematode |
| F09F7.3 | NEK (NEver in mitosis Kinase) Like | F09F7.3 RNAi in the adulthood extends mean and maximum lifespan by 8 and 22%, respectively [23144747]. | Nematode |
| T23D8.3 | More Of MS | T23D8.3 RNAi in the adulthood extends mean and maximum lifespan by 26% and 35, respectively [23144747]. | Nematode |
| asb-1 | ATP Synthase B homolog | asb-1 RNAi in the adulthood extends the mean lifespan by 7% without changing the maximum lifespan [23144747]. | Nematode |
| rpa-1 | Replication Protein A homolog 1 | rpa-1 RNAi in the adulthood extends the mean and maximum lifespan by 5 and 22%, respectively [23144747]. | Nematode |
| rps-12 | Ribosomal Protein, Small subunit | rps-12 RNAi in the adulthood extends mean and maximum lifespan by 12 and 22%, respectively [23144747]. | Nematode |
| R02D3.3 | — | R02D3.3 RNAi in the adulthood extends mean and maximum lifespan by 13 and 22%, respectively [23144747]. | Nematode |
| age-2 | — | Homocygous age-2 mutation increases mean (+43%, +31%, +38%) and maximum (+29%, +36%, +18%)) lifespan by about 20%. age-2 mutant exhibit normal motility, slightly higher swimming rates, reduced fertility and somewhat longer development times and slightly larger size at the first egg laying. Lifespan is extended by reducing the initial mortality rate. age-2 mutation complements other aging gene mutations such as age-1, daf-2, spe-26, clk-1, clk-3 and gro-1. A age-1 age-2 double mutant lives longer than animals with individual mutations and exhibits a longer lifespan at 25 degree Celsius than at 20 degree Celsius [10219000]. | Nematode |
| rab-10 | RAB family | rab-10 RNA interference significantly extends lifespan of wild-type by 14 - 16%, of daf-16 mutants by 47%, and of daf-2 by 46%, but fails to significantly further extend lifespan of eat-2 mutants. rab-10 RNAi does not affect pumping, but similar to DR reduces and delays reproduction as well as cause a slender appearance. rab-10 mRNA is 2-fold downregulated in response to DR [16103914]. rab-10 RNAi significantly reduces paralysis in Q35YFP transgenic animals [18331616]. | Nematode |
