Factors

We need to know every factor which determines lifespan.

Lifespan factors often but not always originate from defined genetic elements. They are not just genes, by definition they can be anything for which a Classifications schema can be build for that is related to the regulation of lifespan, such entities may include Single-Nucleotide Polymorphism, transcript variants, proteins and their complexes, compounds (i.e. small molecules like metabolites and drugs), etc. A factor should be based on a defined molecular entity or genomic position and been classified. It shall be highly flexible and scalable Concept.

While individual lifespan factors within each species or precise defined molecular entities will be captured within the Lifespan App, Data Entries of the Data App may summarize for instance the relevance of each factor class (e.g. homologous group; chemical derivate of related structure and properties, etc.) as well as draw overall conclusions. o

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  • symbol name observation species
    SH3BP4 SH3-domain binding protein 4 SH3BP4 was not found to be associated with longevity [21612516]. Human
    CFLAR CASP8 and FADD-like apoptosis regulator CFLAR was not found to be associated with longevity [21612516]. Human
    TAF5L TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa TAF5L was not found to be associated with longevity [21612516]. Human
    KCNH1 potassium voltage-gated channel, subfamily H (eag-related), member 1 KCNH1 was not found to be associated with longevity [21612516]. Human
    TMEM61 transmembrane protein 61 TMEM61 was not found to be associated with longevity [21612516]. Human
    IBRDC2 ring finger protein 144B IBRDC2 was not found to be associated with longevity [17903295]. Human
    OR4Q3 olfactory receptor, family 4, subfamily Q, member 3 OR4Q3 was not found to be associated with longevity [17903295]. Human
    MYLIP myosin regulatory light chain interacting protein MYLIP was not found to be associated with longevity [17903295]. Human
    NXPH2 neurexophilin 2 NXPH2 was not found to be associated with longevity [17903295]. Human
    BIN1 bridging integrator 1 BIN1 was not found to be associated with longevity [22445811]. Human
    CD2AP CD2-associated protein CD2AP was not found to be associated with longevity [22445811]. Human
    CR1 complement component (3b/4b) receptor 1 (Knops blood group) CR1 was not found to be associated with longevity [22445811]. Human
    CD33 CD33 molecule CD33 was not found to be associated with longevity [22445811]. Human
    EPHA1 EPH receptor A1 EPHA1 was not found to be associated with longevity [22445811]. Human
    PICALM phosphatidylinositol binding clathrin assembly protein PICALM was not found to be associated with longevity [22445811]. Human
    MS4A6A membrane-spanning 4-domains, subfamily A, member 6A MS4A6A was not found to be associated with longevity [22445811]. Human
    ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7 ABCA7 was not found to be associated with longevity [22445811]. Human
    CDKN2B-AS1 CDKN2B antisense RNA 1 CDKN2B-AS1 was found to be associated with longevity [24163049]. CDKN2B-AS1 was not found to be associated with longevity [24163049]. Human
    C4B complement component 4B (Chido blood group) Genetic variations in C4B are not associated with longevity in Italian [10219002]. Human
    C3 complement component 3 Genetic variations in C3 are not associated with longevity in Italian [10219002]. Human
    CFB complement factor B Genetic variations in CFB are not associated with longevity in Italian [10219002]. Human
    C4A complement component 4A (Rodgers blood group) Genetic variations in C4A are not associated with longevity in Italian [10219002]. Human
    IGSF4 cell adhesion molecule 1 IGSF4 was found to be associated with longevity [22279548]. IGSF4 was not found to be associated with longevity [21612516]. Human
    SORCS1 sortilin-related VPS10 domain containing receptor 1 SORCS1 was found to be associated with longevity [22279548]. SORCS1 was not found to be associated with longevity [21612516]. SORCS1 was found to be associated with longevity [24244950]. Human
    SUMF1 sulfatase modifying factor 1 SUMF1 was found to be associated with longevity [22279548]. SUMF1 was not found to be associated with longevity [21612516]. Human
    Factors are an extension of GenAge and GenDR.

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