Factors

We need to know every factor which determines lifespan.

Lifespan factors often but not always originate from defined genetic elements. They are not just genes, by definition they can be anything for which a Classifications schema can be build for that is related to the regulation of lifespan, such entities may include Single-Nucleotide Polymorphism, transcript variants, proteins and their complexes, compounds (i.e. small molecules like metabolites and drugs), etc. A factor should be based on a defined molecular entity or genomic position and been classified. It shall be highly flexible and scalable Concept.

While individual lifespan factors within each species or precise defined molecular entities will be captured within the Lifespan App, Data Entries of the Data App may summarize for instance the relevance of each factor class (e.g. homologous group; chemical derivate of related structure and properties, etc.) as well as draw overall conclusions. o

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  • symbol name observation species
    C8orf47 chromosome 8 open reading frame 47 C8orf47 was found to be associated with longevity [22445811]. Human
    ERBB4 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) ERBB4 was found to be associated with longevity [22445811]. Human
    NAAA N-acylethanolamine acid amidase NAAA was found to be associated with longevity [22445811]. Human
    ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 ADAMTS6 was found to be associated with longevity [22445811]. Human
    SLCO1B1 solute carrier organic anion transporter family, member 1B1 SLCO1B1 was found to be associated with longevity [22445811]. Human
    CDKN2B-AS1 CDKN2B antisense RNA 1 CDKN2B-AS1 was found to be associated with longevity [24163049]. CDKN2B-AS1 was not found to be associated with longevity [24163049]. Human
    MT-RNR2 An single nucleotide polymorphism in MT-RNR2 is associated with longevity [18759861]. Human
    ERGIC1 endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1 ERGIC1 was found to be associated with longevity [22279548]. Human
    CTNNA3 catenin (cadherin-associated protein), alpha 3 CTNNA3 was found to be associated with longevity [22279548]. Human
    BRE brain and reproductive organ-expressed (TNFRSF1A modulator) BRE was found to be associated with longevity [22279548]. Human
    H6PD hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase) H6PD was found to be associated with longevity [22279548]. Human
    UBE2H ubiquitin-conjugating enzyme E2H (UBC8 homolog, yeast) UBE2H was found to be associated with longevity [22279548]. Human
    CSMD3 CUB and Sushi multiple domains 3 CSMD3 was found to be associated with longevity [22279548]. Human
    NDUFA11 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 11, 14.7kDa NDUFA11 was found to be associated with longevity [22279548]. Human
    SYT13 synaptotagmin XIII SYT13 was found to be associated with longevity [22279548]. Human
    CARD14 caspase recruitment domain family, member 14 CARD14 was found to be associated with longevity [22279548]. Human
    C9orf94 ADAMTS-like 1 C9orf94 was found to be associated with longevity [22279548]. Human
    TRIM25 tripartite motif containing 25 TRIM25 was found to be associated with longevity [22279548]. Human
    PIG38 ecto-NOX disulfide-thiol exchanger 1 PIG38 was found to be associated with longevity [22279548]. Human
    NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon NFKBIE was found to be associated with longevity [22279548]. Human
    PROM1 prominin 1 PROM1 was found to be associated with longevity [22279548]. Human
    WWOX WW domain containing oxidoreductase WWOX was found to be associated with longevity [22279548]. WWOX was found to be associated with longevity [24244950]. Human
    KIF13B kinesin family member 13B KIF13B was found to be associated with longevity [22279548]. Human
    RAD51L3 RAD51-like 3 (S. cerevisiae) RAD51L3 was found to be associated with longevity [22279548]. Human
    KLRF1 killer cell lectin-like receptor subfamily F, member 1 KLRF1 was found to be associated with longevity [22279548]. Human
    Factors are an extension of GenAge and GenDR.

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