Factors

We need to know every factor which determines lifespan.

Lifespan factors often but not always originate from defined genetic elements. They are not just genes, by definition they can be anything for which a Classifications schema can be build for that is related to the regulation of lifespan, such entities may include Single-Nucleotide Polymorphism, transcript variants, proteins and their complexes, compounds (i.e. small molecules like metabolites and drugs), etc. A factor should be based on a defined molecular entity or genomic position and been classified. It shall be highly flexible and scalable Concept.

While individual lifespan factors within each species or precise defined molecular entities will be captured within the Lifespan App, Data Entries of the Data App may summarize for instance the relevance of each factor class (e.g. homologous group; chemical derivate of related structure and properties, etc.) as well as draw overall conclusions. o

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  • Species: + -
  • symbol name observation species
    AGTR1 angiotensin II receptor, type 1 AGTR1 was found to be associated with longevity [22569962]. AGTR1 was not found to be associated with longevity [22569962]. Human
    AKT1 v-akt murine thymoma viral oncogene homolog 1 AKT1 was found to be associated with longevity [19489743]. AKT1 was found to be associated with longevity [22929028]. AKT1 was found to be associated with longevity [22929028]. AKT1 was found to be associated with longevity [22929028]. AKT1 was found to be associated with longevity [22929028]. AKT1 was found to be associated with longevity [22929028]. AKT1 was found to be associated with longevity [22929028]. AKT1 was found to be associated with longevity [22929028]. AKT1 was not found to be associated with longevity [22929028]. Human
    GHRHR growth hormone releasing hormone receptor GHRHR was found to be associated with longevity [22406557]. GHRHR was not found to be associated with longevity [19489743]. Human
    MMP9 matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) MMP9 was found to be associated with longevity [17261792]. MMP9 was not found to be associated with longevity [17261792]. Human
    IRS2 insulin receptor substrate 2 IRS2 was found to be associated with longevity [19887537]. IRS2 was not found to be associated with longevity [19489743]. Human
    FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32) FCGR2A was found to be associated with longevity [16893392]. FCGR2A was not found to be associated with longevity [16893392]. Human
    MTP microsomal triglyceride transfer protein MTP was found to be associated with longevity [15911777]. MTP was found to be associated with longevity [22496539]. MTP was not found to be associated with longevity [23273182]. MTP was not found to be associated with longevity [14615589]. MTP was found to be associated with longevity [18034366]. Human
    SIRT3 sirtuin 3 SIRT3 was found to be associated with longevity [14580859]. SIRT3 was found to be associated with longevity [15676284]. SIRT3 was found to be associated with longevity [15676284]. SIRT3 was found to be associated with longevity [19367319]. SIRT3 was found to be associated with longevity [19367319]. SIRT3 was not found to be associated with longevity [19367319]. SIRT3 was found to be associated with longevity [17989723]. SIRT3 was not found to be associated with longevity [23839864]. SIRT3 was found to be associated with longevity [23839864]. Human
    VDR vitamin D (1,25- dihydroxyvitamin D3) receptor VDR was found to be associated with longevity [21051524]. VDR was not found to be associated with longevity [20407924]. VDR was found to be associated with longevity [20407924]. Human
    IL-6 interleukin 6 (interferon, beta 2) IL-6 was found to be associated with longevity [15664628]. IL-6 was found to be associated with longevity [11500818]. IL-6 was not found to be associated with longevity [15236771]. IL-6 was not found to be associated with longevity [11772517]. Human
    FOXO3A forkhead box O3 FOXO3A was found to be associated with longevity [19415983]. FOXO3A was found to be associated with longevity [20849522]. FOXO3A was found to be associated with longevity [19489743]. FOXO3A was found to be associated with longevity [21418511]. FOXO3A was not found to be associated with longevity [19489743]. FOXO3A was found to be associated with longevity [19196970]. FOXO3A was found to be associated with longevity [25038186]. FOXO3A was not found to be associated with longevity [25038186]. Human
    CLU clusterin CLU was found to be associated with longevity [16804001]. CLU was not found to be associated with longevity [22445811]. Human
    PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha PPARGC1A was found to be associated with longevity [23186209]. PPARGC1A was not found to be associated with longevity [15582274]. Human
    LPA lipoprotein, Lp(a) LPA was found to be associated with longevity [11269751]. LPA was not found to be associated with longevity [9622284]. Human
    FOXO1A forkhead box O1 FOXO1A was found to be associated with longevity [17903295]. FOXO1A was found to be associated with longevity [17903295]. FOXO1A was not found to be associated with longevity [19489743]. Human
    ESR1 estrogen receptor 1 ESR1 was found to be associated with longevity [20819792]. ESR1 was found to be associated with longevity [20599431]. ESR1 was found to be associated with longevity [20819792]. ESR1 was found to be associated with longevity [20819792]. ESR1 was not found to be associated with longevity [20599431]. Human
    SIRT1 sirtuin 1 SIRT1 was found to be associated with longevity [21972126; 16257164; 16257164; 16257164; 16257164; 16257164; 21972126; 20633545]. SIRT1 was not found to be associated with longevity [16257164; 18765803].SIRT1 was found to be associated with longevity [23505545]. SIRT1 was found to be associated with longevity [23450480]. SIRT1 was not found to be associated with longevity [23450480]. Human
    KIR2DS4 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 4 KIR2DS4 was found to be associated with longevity [15130674]. KIR2DS4 was found to be associated with longevity [15130674]. KIR2DS4 was not found to be associated with longevity [15130674]. Human
    ADIPOQ10 adiponectin, C1Q and collagen domain containing ADIPOQ was found to be associated with longevity [18511746]. ADIPOQ was found to be associated with longevity [18511746]. ADIPOQ was found to be associated with longevity [23339001]. ADIPOQ was found to be associated with longevity [18511746]. ADIPOQ was found to be associated with longevity [18511746]. ADIPOQ was not found to be associated with longevity [18765803]. Human
    MTHFR methylenetetrahydrofolate reductase (NAD(P)H) MTHFR was found to be associated with longevity [10583447]. MTHFR was found to be associated with longevity [20003469]. MTHFR was found to be associated with longevity [9106548]. MTHFR was found to be associated with longevity [15621215]. MTHFR was found to be associated with longevity [20003469]. MTHFR was not found to be associated with longevity [9105559]. Human
    PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid) PTPN22 was found to be associated with longevity [21113673]. PTPN22 was not found to be associated with longevity [21113673]. Human
    SHC1 SHC (Src homology 2 domain containing) transforming protein 1 SHC1 was found to be associated with longevity [15036421]. SHC1 was found to be associated with longevity [15036421]. SHC1 was found to be associated with longevity [15036421]. SHC1 was found to be associated with longevity [15036421]. SHC1 was found to be associated with longevity [14530863]. SHC1 was found to be associated with longevity [14530863]. SHC1 was found to be associated with longevity [14530863]. SHC1 was found to be associated with longevity [14530863]. SHC1 was not found to be associated with longevity [19489743]. Human
    TNF tumor necrosis factor The frequency of the -308 polymorphism in the TNF gene was analyzed in 71 healthy elders, aged 80 to 96 years (mean 86.2 years). The control samples were obtained from 99 young (from 21 - 54 years; mean 35.2 years) healthy individuals unrelated to elders were studied, age ranged from 80 to 96 years (mean 86.2 years). The TNF2 allele was increased in the elder group when compared to young controls [16269080].TNF was found to be associated with longevity [20518833]. TNF was found to be associated with longevity [18511747]. TNF was found to be associated with longevity [12714268]. TNF was found to be associated with longevity [12714268]. TNF was found to be associated with longevity [12676903]. TNF was found to be associated with longevity [11640949]. TNF was found to be associated with longevity [21299522]. TNF was found to be associated with longevity [21299522]. TNF was not found to be associated with longevity [12676903]. TNF was found to be associated with longevity [16269080]. TNF was not found to be associated with longevity [11640949]. Human
    TH tyrosine hydroxylase Polymorphyc repeats in intron 1 (Short and Long alleles) of the TH gene were examined in 196 centenarians (143 females and 53 males) and 358 controls (196 females and 162 male; 10-85 years old). A significant loss of LL homozygous genotypes was found at the THO locus in male but not in female centenarians with respect to matched controls [9887369].TH was found to be associated with longevity [12297342]. TH was found to be associated with longevity [21407269]. TH was found to be associated with longevity [19367319]. TH was not found to be associated with longevity [19367319]. TH was found to be associated with longevity [11053670]. TH was found to be associated with longevity [17989723]. Human
    PON1 paraoxonase 1 Polymorphism at codon 192 (Gln/Arg) of the PON1 gene was examined in 256 healthy Caucasian men (69.8 +/- 4.0 years). Gln homozygotes are more frequent in aging than Arg allele carriers [12889841].PON1 was found to be associated with longevity [15050299]. PON1 was found to be associated with longevity [15050299]. PON1 was found to be associated with longevity [17903295]. PON1 was found to be associated with longevity [12082503]. PON1 was found to be associated with longevity [12082503]. PON1 was found to be associated with longevity [12082503]. PON1 was found to be associated with longevity [16799134]. PON1 was found to be associated with longevity [16799134]. PON1 was found to be associated with longevity [15050299]. PON1 was not found to be associated with longevity [15241482]. PON1 was found to be associated with longevity [15241482]. PON1 was not found to be associated with longevity [20362697]. PON1 was not found to be associated with longevity [18034366]. Human
    Factors are an extension of GenAge and GenDR.

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