Factors

We need to know every factor which determines lifespan.

Lifespan factors often but not always originate from defined genetic elements. They are not just genes, by definition they can be anything for which a Classifications schema can be build for that is related to the regulation of lifespan, such entities may include Single-Nucleotide Polymorphism, transcript variants, proteins and their complexes, compounds (i.e. small molecules like metabolites and drugs), etc. A factor should be based on a defined molecular entity or genomic position and been classified. It shall be highly flexible and scalable Concept.

While individual lifespan factors within each species or precise defined molecular entities will be captured within the Lifespan App, Data Entries of the Data App may summarize for instance the relevance of each factor class (e.g. homologous group; chemical derivate of related structure and properties, etc.) as well as draw overall conclusions. o

prometheus--2.jpg

  • Species: + -
  • symbol name observation species
    PVRL2 PVRL2 was found to be associated with longevity [24924924]. PVRL2 was not found to be associated with longevity [24924924]. Human
    PTK2 PTK2 was found to be associated with longevity [24930376]. PTK2 was not found to be associated with longevity [24930376]. Human
    CDKN2B-AS1 CDKN2B antisense RNA 1 CDKN2B-AS1 was found to be associated with longevity [24163049]. CDKN2B-AS1 was not found to be associated with longevity [24163049]. Human
    IGSF4 cell adhesion molecule 1 IGSF4 was found to be associated with longevity [22279548]. IGSF4 was not found to be associated with longevity [21612516]. Human
    SORCS1 sortilin-related VPS10 domain containing receptor 1 SORCS1 was found to be associated with longevity [22279548]. SORCS1 was not found to be associated with longevity [21612516]. SORCS1 was found to be associated with longevity [24244950]. Human
    SUMF1 sulfatase modifying factor 1 SUMF1 was found to be associated with longevity [22279548]. SUMF1 was not found to be associated with longevity [21612516]. Human
    Downstream of FOXO3A Downstream of FOXO3A was found to be associated with longevity [19196970]. Downstream of FOXO3A was not found to be associated with longevity [19196970]. Human
    ADRB2 adrenergic, beta-2-, receptor, surface ADRB2 was found to be associated with longevity [23020224]. ADRB2 was not found to be associated with longevity [23020224]. Human
    RANTES ATP synthase, H+ transporting, mitochondrial Fo complex, subunit G RANTES was not found to be associated with longevity [22265023]. RANTES was found to be associated with longevity [22265023]. Human
    ADIPQO adiponectin, C1Q and collagen domain containing ADIPQO was not found to be associated with longevity [20201642]. ADIPQO was found to be associated with longevity [20201642]. Human
    ADARB2 adenosine deaminase, RNA-specific, B2 ADARB2 was found to be associated with longevity [20011587]. ADARB2 was not found to be associated with longevity [20011587]. Human
    TNFa tumor necrosis factor TNFa was found to be associated with longevity [17989723]. TNFA was not found to be associated with longevity [21865054]. Human
    VEGFA vascular endothelial growth factor A VEGFA was found to be associated with longevity [17574707]. VEGFA was not found to be associated with longevity [17574707]. Human
    TH tyrosine hydroxylase TH was not found to be associated with longevity [12297342]. TH was found to be associated with longevity [12297342]. Human
    FAS Fas (TNF receptor superfamily, member 6) FAS was not found to be associated with longevity [11965496]. FAS was found to be associated with longevity [22279548]. Human
    IL2 interleukin 2 IL2 was found to be associated with longevity [21299522]. IL2 was not found to be associated with longevity [16518704]. Human
    TSPAN32 tetraspanin 32 TSPAN32 was found to be associated with longevity [19367319]. TSPAN32 was not found to be associated with longevity [19367319]. Human
    KRTAP5-6 keratin associated protein 5-6 KRTAP5-6 was found to be associated with longevity [19367319]. KRTAP5-6 was not found to be associated with longevity [19367319]. Human
    DEAF1 deformed epidermal autoregulatory factor 1 (Drosophila) DEAF1 was found to be associated with longevity [19367319]. DEAF1 was found to be associated with longevity [19367319]. DEAF1 was found to be associated with longevity [19367319]. DEAF1 was not found to be associated with longevity [19367319]. Human
    HRAS1 v-Ha-ras Harvey rat sarcoma viral oncogene homolog HRAS1 was found to be associated with longevity [19367319]. HRAS1 was not found to be associated with longevity [19367319]. Human
    IL1RN interleukin 1 receptor antagonist IL1RN was found to be associated with longevity [12714264]. IL1RN was found to be associated with longevity [11640949]. IL1RN was not found to be associated with longevity [12714264]. IL1RN was not found to be associated with longevity [11640949]. Human
    IL1B interleukin 1, beta IL1B was found to be associated with longevity [12714264]. IL1B was found to be associated with longevity [11640949]. IL1B was found to be associated with longevity [11640949]. IL1B was not found to be associated with longevity [12714264]. IL1B was not found to be associated with longevity [11640949]. Human
    IL1A interleukin 1, alpha IL1A was found to be associated with longevity [12714264]. IL1A was found to be associated with longevity [11640949]. IL1A was not found to be associated with longevity [12714264]. IL1A was not found to be associated with longevity [11640949]. Human
    CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) CDKN1A was found to be associated with longevity [20126416]. CDKN1A was found to be associated with longevity [20126416]. CDKN1A was not found to be associated with longevity [20126416]. Human
    GSTM1 glutathione S-transferase mu 1 GSTM1 was found to be associated with longevity [9654200]. GSTM1 was found to be associated with longevity [9654200]. GSTM1 was found to be associated with longevity [16574194]. GSTM1 was not found to be associated with longevity [15195682]. Human
    • Page 1 of 4
    • 25 of 84 factors
    Factors are an extension of GenAge and GenDR.

    Comment on This Data Unit