Denigma

MDH1

Symbol: MDH1
Name: Malate DeHydrogenase 1
Entrez gene ID: 853777
Ensembl gene ID: YKL085W
Species: Yeast (Taxid: 4932)

Functional description:
Mdh1p; Mitochondrial malate dehydrogenase, catalyzes interconversion of malate and oxaloacetate; involved in the tricarboxylic acid (TCA) cycle; phosphorylated [Source:SGD;Acc:S000001568] [Ensembl]

Observation:

Overexpression of MDH1 extends replicative lifespan by 25% and does not synergize with 0.5% glucose restriction [18381895].



Interventions:
  • MDH1 overexpression +25%

    • Assays: Replicative Lifespan

    Classification:
  • Aging-Suppressor
  • Positive Aging-Suppressor
  • DR-Essential


    • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

    • Homologs
  • MDH2 (9606)
  • MDH2 (9598)
  • MDH2 (9615)
  • Mdh2 (10090)
  • Mdh2 (10116)
  • MDH2 (9031)
  • zgc:64133 (7955)
  • CG7998 (7227)
  • AgaP_AGAP001903 (7165)
  • mdh-1 (6239)
  • SPCC306.08c (4896)
  • MDH1 (4932)
  • KLLA0F25960g (28985)
  • GeneID:2680415 (148305)
  • NCU04899 (5141)
  • AT1G53240 (3702)
  • AT3G15020 (3702)
  • Os01g0649100 (4530)
  • Os05g0574400 (4530)

    • Orthologs
  • SPCC306.08c (4896)
  • Mdh2 (10116)
  • Mdh2 (10090)
  • CG10748 (7227)
  • CG10749 (7227)
  • MDH2 (9606)
  • mdh-1 (6239)
  • CG7998 (7227)
  • LOC719983 (9544)
  • SPCC306.08c (4896)
  • Mdh2 (10116)
  • Mdh2 (10090)
  • CG10748 (7227)
  • CG10749 (7227)
  • MDH2 (9606)
  • mdh-1 (6239)
  • CG7998 (7227)
  • LOC719983 (9544)



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