LAT1

Symbol: LAT1
Alias: PDA2; ODP2
Entrez gene ID: 855653
Ensembl gene ID: YNL071W
Species: Yeast (Taxid: 4932)

Functional description:
Lat1p; Dihydrolipoamide acetyltransferase component (E2) of pyruvate dehydrogenase complex, which catalyzes the oxidative decarboxylation of pyruvate to acetyl-CoA [Source:SGD;Acc:S000005015] [Ensembl]

Observation:

LAT1 is suggested to play a role in lifespan extension of DR. Deleting LAT1 abolishes replicative lifespan extension induced by 0.5% and 0.05% glucose restriction. In contrast, overexpressing Lat1 extends replicative lifespan, and this lifespan extension was not further increased by 0.5% glucose restriction. Similar to DR, replicative lifespan extension by LAT1 overexpression largely requires mitochondrial respiration [17200108]. Overexpressing LAT1 extends lifespan (20% mean lifespan increase) and this lifespan extension is not further increased by DR. Similar to DR, lifespan extension by Lat1 overexpression largely requires mitochondrial respiration indicating mitochondrial metabolism plays an important role in DR. Interestingly, LAT1 overexpression does not require the Sir2 family to extend lifespan. Lat1 is also a limiting longevity factor in non-dividing cells in that overexpressing LAT1 extends cell survival during prolonged culture at stationary phase.



Interventions:
  • LAT1 overexpression +20%
  • LAT1 deletion

  • Assays: Replicative Lifespan

    Classification:
  • Aging-Suppressor
  • Positive Aging-Suppressor
  • DR-Essential


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • DLAT (9606)
  • DLAT (9598)
  • DLAT (9615)
  • DLAT (9913)
  • Dlat (10090)
  • Dlat (10116)
  • DLAT (9031)
  • dlat (7955)
  • CG5261 (7227)
  • AgaP_AGAP007975 (7165)
  • F23B12.5 (6239)
  • SPCC794.07 (4896)
  • LAT1 (4932)
  • KLLA0F04741g (28985)
  • AGOS_AER364W (33169)
  • GeneID:2680788 (148305)
  • NCU07659 (5141)
  • AT3G13930 (3702)
  • AT1G54220 (3702)
  • Os02g0105200 (4530)
  • Os07g0410100 (4530)
  • Os06g0105400 (4530)

  • Orthologs
  • Pdhx (10090)
  • DLAT (9544)
  • C30H6.7 (6239)
  • Dbt (10116)
  • SPCC794.07 (4896)
  • DBT (9544)
  • CG5599 (7227)
  • LOC713467 (9544)
  • ZK669.4 (6239)
  • DLAT (9606)
  • Dlat (10090)
  • Pdhx (10116)
  • DBT (9606)
  • CG5261 (7227)
  • F23B12.5 (6239)
  • PDHX (9606)
  • Dbt (10090)
  • Dlat (10116)
  • Pdhx (10090)
  • DLAT (9544)
  • C30H6.7 (6239)
  • Dbt (10116)
  • SPCC794.07 (4896)
  • DBT (9544)
  • CG5599 (7227)
  • LOC713467 (9544)
  • ZK669.4 (6239)
  • DLAT (9606)
  • Dlat (10090)
  • Pdhx (10116)
  • DBT (9606)
  • CG5261 (7227)
  • F23B12.5 (6239)
  • PDHX (9606)
  • Dbt (10090)
  • Dlat (10116)
  • Pdhx (10090)
  • DLAT (9544)
  • C30H6.7 (6239)
  • Dbt (10116)
  • SPCC794.07 (4896)
  • DBT (9544)
  • CG5599 (7227)
  • LOC713467 (9544)
  • ZK669.4 (6239)
  • DLAT (9606)
  • Dlat (10090)
  • Pdhx (10116)
  • DBT (9606)
  • CG5261 (7227)
  • F23B12.5 (6239)
  • PDHX (9606)
  • Dbt (10090)
  • Dlat (10116)



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