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Symbol: ISC1 Name: Inositol phosphoSphingolipid phospholipase C 1 Entrez gene ID: 856739 Ensembl gene ID: YER019W Species: Yeast (Taxid: 4932) Functional description: Isc1p; Mitochondrial membrane localized inositol phosphosphingolipid phospholipase C, hydrolyzes complex sphingolipids to produce ceramide; activated by phosphatidylserine, cardiolipin, and phosphatidylglycerol; mediates Na+ and Li+ halotolerance [Source:SGD;Acc:S000000821] [Ensembl] Observation: ISC1 deletion decreases chronological lifespan [21707788; 21707788]. CTA1 overexpression partially suppresses the shortened lifespan by ISC1. Deletion of SIT4 totally rescues the short lifespan of ISC1 mutants [21707788]. HOG1 deletion partially suppresses the premature aging phenotype and short lifespan of ISC1 deletion [22445853]. Interventions: Assays: Chronological Lifespan Classification: Aging Relevance Analysis/Source:  GenAge GenDRHomologs Edit \ Update (Admin) | Delete |
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