Denigma

HST2

Symbol: HST2
Name: Homolog of SIR Two (SIR2) 2
Entrez gene ID: 856092
Ensembl gene ID: YPL015C
Species: Yeast (Taxid: 4932)

Functional description:
Hst2p; Cytoplasmic member of the silencing information regulator 2 (Sir2) family of NAD(+)-dependent protein deacetylases; modulates nucleolar (rDNA) and telomeric silencing; possesses NAD(+)-dependent histone deacetylase activity in vitro [Source:SGD;Acc:S000005936] [Ensembl]

Observation:

HST2 overexpression extends replicative lifespan. 0.5% glucose restriction does not increase lifespan of sir2;fob1;hst2 triple mutants [16051752]. DR increases lifespan of all four sir2;fob1;hstX(X = sirtuin) triple mutants [16741098; 17129213].



Interventions:
  • HST2 overexpression

    • Assays: Replicative Lifespan

    Classification:
  • Aging-Suppressor
  • Positive Aging-Suppressor
  • DR-Essential


    • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

    • Homologs
  • SIRT2 (9606)
  • SIRT2 (9598)
  • SIRT2 (9615)
  • SIRT2 (9913)
  • Sirt2 (10090)
  • Sirt2 (10116)
  • sirt2 (7955)
  • Sirt2 (7227)
  • AgaP_AGAP002943 (7165)
  • hst2 (4896)
  • HST2 (4932)
  • KLLA0F11033g (28985)
  • AGOS_AGL018C (33169)
  • GeneID:5048967 (148305)
  • NCU00523 (5141)

    • Orthologs
  • Sirt3 (10090)
  • LOC100425019 (9544)
  • LOC723467 (9544)
  • SIRT3 (9544)
  • sir-2.3 (6239)
  • SIRT2 (9606)
  • Sirt5 (10116)
  • Sirt4 (10116)
  • SIRT5 (9544)
  • Sirt2 (7227)
  • Sirt2 (10116)
  • sir-2.2 (6239)
  • Sirt3 (10116)
  • SIRT5 (9606)
  • SIRT4 (9606)
  • SIRT3 (9606)
  • hst2 (4896)
  • Sirt4 (7227)
  • Sirt5 (10090)
  • Sirt4 (10090)
  • Sirt2 (10090)
  • Sirt3 (10090)
  • LOC100425019 (9544)
  • LOC723467 (9544)
  • SIRT3 (9544)
  • sir-2.3 (6239)
  • SIRT2 (9606)
  • Sirt5 (10116)
  • Sirt4 (10116)
  • SIRT5 (9544)
  • Sirt2 (7227)
  • Sirt2 (10116)
  • sir-2.2 (6239)
  • Sirt3 (10116)
  • SIRT5 (9606)
  • SIRT4 (9606)
  • SIRT3 (9606)
  • hst2 (4896)
  • Sirt4 (7227)
  • Sirt5 (10090)
  • Sirt4 (10090)
  • Sirt2 (10090)
  • Sirt3 (10090)
  • LOC100425019 (9544)
  • LOC723467 (9544)
  • SIRT3 (9544)
  • sir-2.3 (6239)
  • SIRT2 (9606)
  • Sirt5 (10116)
  • Sirt4 (10116)
  • SIRT5 (9544)
  • Sirt2 (7227)
  • Sirt2 (10116)
  • sir-2.2 (6239)
  • Sirt3 (10116)
  • SIRT5 (9606)
  • SIRT4 (9606)
  • SIRT3 (9606)
  • hst2 (4896)
  • Sirt4 (7227)
  • Sirt5 (10090)
  • Sirt4 (10090)
  • Sirt2 (10090)

    • Note: Overexpression results in replicative lifespan extension. ChronologicalLS extension or no life span prolongation during CR accordingly

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