Symbol: HDA1
Name: Histone DeAcetylase 1
Entrez gene ID: 855710
Ensembl gene ID: YNL021W
Species: Yeast
(Taxid: 4932)
Functional description:
Hda1p; Putative catalytic subunit of a class II histone deacetylase complex that also contains Hda2p and Hda3p; Hda1p interacts with the Hda2p-Hda3p subcomplex to form an active tetramer; deletion increases histone H2B, H3 and H4 acetylation [Source:SGD;Acc:S000004966] [Ensembl]
Observation:
Deletion of HDA1 has no effect on longevity under AL, but acts synergistically with 0.1% glucose restriction to increase replicative lifespan [12213553]. Deletion of HDA1 leads to a slightly increased chronological lifespan [19801973]. Deletion of HDA1 has no effect on the wild-type lifespan in the short-lifespan of YSK771 strain, but suppresses the short-lifespan of SIR3 mutants [10512855].
Interventions:
HDA1 deletion
Assays:
Replicative Lifespan
Classification:
Gero-Suppressant
No Age Effect
Aging Relevance Analysis/Source:
GenAge
GenDR
Homologs
clr3
(4896)
HDA1
(4932)
KLLA0E08383g
(28985)
AGOS_ADL216C
(33169)
GeneID:2674943
(148305)
NCU01525
(5141)
Orthologs
HDAC9
(9606)
LOC718225
(9544)
clr3
(4896)
HDAC4
(7227)
Hdac4
(10116)
HDAC6
(9606)
HDAC4
(9606)
RGD1563092
(10116)
Hdac10
(10090)
F41H10.6
(6239)
Hdac7
(10090)
HDAC6
(9544)
HDAC5
(9606)
Hdac9
(10116)
Hdac9
(10090)
hda-6
(6239)
LOC715698
(9544)
HDAC6
(7227)
Hdac5
(10090)
Hdac6
(10090)
LOC711456
(9544)
Hdac4
(10090)
F43G6.11
(6239)
HDAC10
(9606)
hda-4
(6239)
Hdac6
(10116)
LOC706667
(9544)
Hdac5
(10116)
Hdac10
(10116)
Hdac7
(10116)
HDAC7
(9606)
LOC708314
(9544)
HDAC9
(9606)
LOC718225
(9544)
clr3
(4896)
HDAC4
(7227)
Hdac4
(10116)
HDAC6
(9606)
HDAC4
(9606)
RGD1563092
(10116)
Hdac10
(10090)
F41H10.6
(6239)
Hdac7
(10090)
HDAC6
(9544)
HDAC5
(9606)
Hdac9
(10116)
Hdac9
(10090)
hda-6
(6239)
LOC715698
(9544)
HDAC6
(7227)
Hdac5
(10090)
Hdac6
(10090)
LOC711456
(9544)
Hdac4
(10090)
F43G6.11
(6239)
HDAC10
(9606)
hda-4
(6239)
Hdac6
(10116)
LOC706667
(9544)
Hdac5
(10116)
Hdac10
(10116)
Hdac7
(10116)
HDAC7
(9606)
LOC708314
(9544)
HDAC9
(9606)
LOC718225
(9544)
clr3
(4896)
HDAC4
(7227)
Hdac4
(10116)
HDAC6
(9606)
HDAC4
(9606)
RGD1563092
(10116)
Hdac10
(10090)
F41H10.6
(6239)
Hdac7
(10090)
HDAC6
(9544)
HDAC5
(9606)
Hdac9
(10116)
Hdac9
(10090)
hda-6
(6239)
LOC715698
(9544)
HDAC6
(7227)
Hdac5
(10090)
Hdac6
(10090)
LOC711456
(9544)
Hdac4
(10090)
F43G6.11
(6239)
HDAC10
(9606)
hda-4
(6239)
Hdac6
(10116)
LOC706667
(9544)
Hdac5
(10116)
Hdac10
(10116)
Hdac7
(10116)
HDAC7
(9606)
LOC708314
(9544)
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