Denigma

HDA1

Symbol: HDA1
Name: Histone DeAcetylase 1
Entrez gene ID: 855710
Ensembl gene ID: YNL021W
Species: Yeast (Taxid: 4932)

Functional description:
Hda1p; Putative catalytic subunit of a class II histone deacetylase complex that also contains Hda2p and Hda3p; Hda1p interacts with the Hda2p-Hda3p subcomplex to form an active tetramer; deletion increases histone H2B, H3 and H4 acetylation [Source:SGD;Acc:S000004966] [Ensembl]

Observation:

Deletion of HDA1 has no effect on longevity under AL, but acts synergistically with 0.1% glucose restriction to increase replicative lifespan [12213553]. Deletion of HDA1 leads to a slightly increased chronological lifespan [19801973]. Deletion of HDA1 has no effect on the wild-type lifespan in the short-lifespan of YSK771 strain, but suppresses the short-lifespan of SIR3 mutants [10512855].



Interventions:
  • HDA1 deletion

    • Assays: Replicative Lifespan

    Classification:
  • Gero-Suppressant
  • No Age Effect


    • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

    • Homologs
  • clr3 (4896)
  • HDA1 (4932)
  • KLLA0E08383g (28985)
  • AGOS_ADL216C (33169)
  • GeneID:2674943 (148305)
  • NCU01525 (5141)

    • Orthologs
  • HDAC9 (9606)
  • LOC718225 (9544)
  • clr3 (4896)
  • HDAC4 (7227)
  • Hdac4 (10116)
  • HDAC6 (9606)
  • HDAC4 (9606)
  • RGD1563092 (10116)
  • Hdac10 (10090)
  • F41H10.6 (6239)
  • Hdac7 (10090)
  • HDAC6 (9544)
  • HDAC5 (9606)
  • Hdac9 (10116)
  • Hdac9 (10090)
  • hda-6 (6239)
  • LOC715698 (9544)
  • HDAC6 (7227)
  • Hdac5 (10090)
  • Hdac6 (10090)
  • LOC711456 (9544)
  • Hdac4 (10090)
  • F43G6.11 (6239)
  • HDAC10 (9606)
  • hda-4 (6239)
  • Hdac6 (10116)
  • LOC706667 (9544)
  • Hdac5 (10116)
  • Hdac10 (10116)
  • Hdac7 (10116)
  • HDAC7 (9606)
  • LOC708314 (9544)
  • HDAC9 (9606)
  • LOC718225 (9544)
  • clr3 (4896)
  • HDAC4 (7227)
  • Hdac4 (10116)
  • HDAC6 (9606)
  • HDAC4 (9606)
  • RGD1563092 (10116)
  • Hdac10 (10090)
  • F41H10.6 (6239)
  • Hdac7 (10090)
  • HDAC6 (9544)
  • HDAC5 (9606)
  • Hdac9 (10116)
  • Hdac9 (10090)
  • hda-6 (6239)
  • LOC715698 (9544)
  • HDAC6 (7227)
  • Hdac5 (10090)
  • Hdac6 (10090)
  • LOC711456 (9544)
  • Hdac4 (10090)
  • F43G6.11 (6239)
  • HDAC10 (9606)
  • hda-4 (6239)
  • Hdac6 (10116)
  • LOC706667 (9544)
  • Hdac5 (10116)
  • Hdac10 (10116)
  • Hdac7 (10116)
  • HDAC7 (9606)
  • LOC708314 (9544)
  • HDAC9 (9606)
  • LOC718225 (9544)
  • clr3 (4896)
  • HDAC4 (7227)
  • Hdac4 (10116)
  • HDAC6 (9606)
  • HDAC4 (9606)
  • RGD1563092 (10116)
  • Hdac10 (10090)
  • F41H10.6 (6239)
  • Hdac7 (10090)
  • HDAC6 (9544)
  • HDAC5 (9606)
  • Hdac9 (10116)
  • Hdac9 (10090)
  • hda-6 (6239)
  • LOC715698 (9544)
  • HDAC6 (7227)
  • Hdac5 (10090)
  • Hdac6 (10090)
  • LOC711456 (9544)
  • Hdac4 (10090)
  • F43G6.11 (6239)
  • HDAC10 (9606)
  • hda-4 (6239)
  • Hdac6 (10116)
  • LOC706667 (9544)
  • Hdac5 (10116)
  • Hdac10 (10116)
  • Hdac7 (10116)
  • HDAC7 (9606)
  • LOC708314 (9544)



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