Denigma

cchl-1

Symbol: cchl-1
Name: Cytochrome C Heme-Lyase
Entrez gene ID: 174713
Ensembl gene ID: T06D8.6
Species: Worm (Taxid: 6239)

Functional description:
Holocytochrome c synthase/heme-lyase; Links covalently the heme group to the apoprotein of cytochrome c (By similarity). [UniProt]

Observation:

cchl-1 RNAi extends mean and maximum lifespan by 55% and 57%, respectively. Lifespan extension by RNAi of cchl-1 is not suppressed by daf-16 [12447374].

cchl-1 RNAi animals have lower ATP content and oxygen consumption [12447374].



Interventions:
  • cchl-1 RNAi +55% +57%

    • Assays: Organismal Lifespan
    Mean: +55
    Maximum: +57

    Classification:
  • DR-Essential Paralog


    • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

    • Homologs
  • hccsa (7955)
  • Cchl (7227)
  • AgaP_AGAP003843 (7165)
  • cchl-1 (6239)
  • SPBC26H8.12 (4896)
  • CYC3 (4932)
  • KLLA0C13123g (28985)
  • AGOS_ADR382W (33169)
  • GeneID:2676111 (148305)
  • NCU05601 (5141)
  • PFL1185c (5833)



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