Cav1

Symbol: Cav1
Name: caveolin, caveolae protein 1
Entrez gene ID: 12389
Ensembl gene ID: ENSMUSG00000007655
Species: Mouse (Taxid: 10090)

Functional description:
Involved in the costimulatory signal essential for T- cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. May act as a scaffolding protein within caveolar membranes. Interacts directly with G- protein alpha subunits and can functionally regulate their activity. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway. [UniProt]

Observation:

Knockout mice are viable and fertile but exhibit an approximately 50% reduction in lifespan probably due to a combination of pulmonary fibrosis, pulmonary hypertension, and cardiac hypertrophy [14690422].



Interventions:
  • Cav1 knockout -50%

  • Assays: Organismal Lifespan
    Mean: -50

    Classification:
  • Aging-Suppressor
  • Negative Aging-Suppressor


  • References:
  • 14690422: Caveolin-1 null (-/-) mice show dramatic reductions in life span.


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • CAV1 (9606)
  • CAV1 (9598)
  • CAV1 (9615)
  • CAV1 (9913)
  • Cav1 (10090)
  • Cav1 (10116)
  • CAV1 (9031)
  • cav1 (7955)



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