Symbol: Cav1 Name: caveolin, caveolae protein 1 Entrez gene ID: 12389 Ensembl gene ID: ENSMUSG00000007655 Species: Mouse (Taxid: 10090) Functional description: Involved in the costimulatory signal essential for T- cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. May act as a scaffolding protein within caveolar membranes. Interacts directly with G- protein alpha subunits and can functionally regulate their activity. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway. [UniProt] Observation: Knockout mice are viable and fertile but exhibit an approximately 50% reduction in lifespan probably due to a combination of pulmonary fibrosis, pulmonary hypertension, and cardiac hypertrophy [14690422]. Interventions: Assays: Organismal Lifespan Mean: -50 Classification: References: Aging Relevance Analysis/Source: Homologs Edit \ Update (Admin) | Delete |
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