Denigma: Factor

GCN4

Symbol: GCN4
Name: Transcriptional activator of amino acid biosynthetic genes in response to amino acid starvation; expression is tightly regulated at both the transcriptional and translational levels
Entrez gene ID: 856709
Species: Yeast (Taxid: 4932)

Functional description:
Gcn4p; Basic leucine zipper (bZIP) transcriptional activator of amino acid biosynthetic genes in response to amino acid starvation; expression is tightly regulated at both the transcriptional and translational levels [Source:SGD;Acc:S000000735] [Ensembl]

Observation:

Deletion of GCN4 increases the replicative lifespan by 10% in the alpha strain [19030232]. GCN4 deletion decreases the lifespan in the alpha and a strain [20657825].

The chronological lifespan of GCN4 deletion is strongly decreased in the a strain [20421943].

Interventions:

GCN4 Deletion +10%

Assays: Replicative Lifespan Chronological Lifespan

Classification:

Aging Associated

Aging-Suppressor

Negative Aging-Suppressor

Gerontogene

Positive Gerontogene

Type:

Gene

References:

20657825: Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation.