Denigma: Factor

GCN2

Symbol: GCN2
Name: General Control Nonderepressible 2
Entrez gene ID: 851877
Ensembl gene ID: YDR283C
Species: Yeast (Taxid: 4932)

Functional description:
Gcn2p; Protein kinase, phosphorylates the alpha-subunit of translation initiation factor eIF2 (Sui2p) in response to starvation; activated by uncharged tRNAs and the Gcn1p-Gcn20p complex; contributes to DNA damage checkpoint control [Source:SGD;Acc:S000002691] [Ensembl]

Observation:

Deletion of GCN2 decreases replicative lifespan by 10% in a strain [18340043]. GCN2 deletion decreases replicative lifespan by 10-20% in both alpha and a strains [19030232].

Interventions:

GCN2 deletion -10 to-20%

Assays: Replicative Lifespan

Classification:

Aging-Suppressor

Negative Aging-Suppressor

Aging Relevance Analysis/Source:

GenAge