ERG6

Symbol: ERG6
Name: ERGosterol biosynthesis 6
Alias: ISE1; LIS1; SED6; VID1
Entrez gene ID: 855003
Ensembl gene ID: YML008C
Species: Yeast (Taxid: 4932)

Functional description:
Erg6p; Delta(24)-sterol C-methyltransferase, converts zymosterol to fecosterol in the ergosterol biosynthetic pathway by methylating position C-24; localized to both lipid particles and mitochondrial outer membrane [Source:SGD;Acc:S000004467] [Ensembl]

Observation:

Deletion of ERG6 cancels out replicative lifespan extension of 0.5% glucose DR and results under DR also into a shorter replicative lifespan than under AL [18690010].



Interventions:
  • ERG6 deletion

  • Assays: Replicative Lifespan

    Classification:
  • Aging-Suppressor
  • Negative Aging-Suppressor
  • DR-Essential


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • erg6 (4896)
  • ERG6 (4932)
  • KLLA0A01738g (28985)
  • AGOS_ADR196W (33169)
  • GeneID:2682181 (148305)
  • NCU03006 (5141)
  • SMT1 (3702)
  • Os07g0206700 (4530)

  • Orthologs
  • erg6 (4896)
  • H14E04.1 (6239)
  • erg6 (4896)
  • H14E04.1 (6239)



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