ERG5

Symbol: ERG5
Name: ERGosterol biosynthesis 5
Alias: CYP61
Entrez gene ID: 855029
Ensembl gene ID: YMR015C
Species: Yeast (Taxid: 4932)

Functional description:
Erg5p; C-22 sterol desaturase, a cytochrome P450 enzyme that catalyzes the formation of the C-22(23) double bond in the sterol side chain in ergosterol biosynthesis; may be a target of azole antifungal drugs [Source:SGD;Acc:S000004617] [Ensembl]

Observation:

Deletion of ERG5 decreases replicative lifespan by 35% in the a strain [18340043], but increases mean chronological lifespan by 26 - 116% (26, 40, 43, 62, 116) in diploid cells [21447998]. Deletion of ERG5 cancels out the replicative lifespan extension of 0.5% glucose restriction [18690010].



Interventions:
  • ERG5 deletion -35 to +116%

  • Assays: Replicative Lifespan Chronological Lifespan

    Classification:
  • Aging-Suppressor
  • Negative Aging-Suppressor
  • Gerontogene
  • Positive Gerontogene
  • DR-Essential


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • erg5 (4896)
  • ERG5 (4932)
  • KLLA0D11242g (28985)
  • GeneID:2683928 (148305)
  • NCU05278 (5141)
  • CYP710A1 (3702)
  • CYP710A3 (3702)
  • CYP710A4 (3702)
  • CYP710A2 (3702)
  • Os01g0210900 (4530)
  • Os01g0211200 (4530)
  • Os01g0211600 (4530)

  • Orthologs
  • erg5 (4896)
  • Cyp310a1 (7227)
  • erg5 (4896)
  • Cyp310a1 (7227)



  • Edit \ Update (Admin) | Delete

    Comment on This Data Unit