CLA4

Symbol: CLA4
Name: CLn Activity dependant 4
Entrez gene ID: 855418
Ensembl gene ID: YNL298W
Species: Yeast (Taxid: 4932)

Functional description:
Cla4p; Cdc42p-activated signal transducing kinase of the PAK (p21-activated kinase) family, along with Ste20p and Skm1p; involved in septin ring assembly, vacuole inheritance, cytokinesis, sterol uptake regulation; phosphorylates Cdc3p and Cdc10p [Source:SGD;Acc:S000005242] [Ensembl]

Observation:

Deletion of CLA4 decreases replicative lifespan by 60% in the alpha strain [18340043; 19030232].



Interventions:
  • CLA4 deletion -60%

  • Assays: Replicative Lifespan

    Classification:
  • Aging-Suppressor
  • Negative Aging-Suppressor


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • PAK2 (9606)
  • PAK2 (9598)
  • PAK2 (9615)
  • Pak2 (10090)
  • Pak2 (10116)
  • PAK2 (9031)
  • pak2a (7955)
  • shk2 (4896)
  • CLA4 (4932)
  • KLLA0A07403g (28985)
  • AGOS_AEL205W (33169)
  • GeneID:2684475 (148305)
  • NCU00406 (5141)



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