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Symbol: CHL1 Name: CHromosome Loss 1 Alias: CTF1; LPA9; MCM12 Entrez gene ID: 856099 Ensembl gene ID: YPL008W Species: Yeast (Taxid: 4932) Functional description: Required to establish sister-chromatid pairing; Chl1p; Probable DNA helicase involved in sister-chromatid cohesion and genome integrity; interacts with ECO1 and CTF18; mutants are defective in silencing, rDNA recombination, aging and the heat shock response; FANCJ-like helicase family member [Source:SGD;Acc:S000005929] [Ensembl]; Probable DNA helicase; involved in sister-chromatid cohesion and genome integrity; interacts with ECO1 and CTF18; mutants are defective in silencing, rDNA recombination, aging and the heat shock response; FANCJ-like helicase family member; mutations in the human homolog, DDX11/ChLR1, cause Warsaw breakage syndrome [SGD] Observation: CHL1 deletion mutant exhibits a shortened mean and maximum lifespan by 36 and 29%, respectively, as well as hypersensitivity to heat stress. CHL1 may modulate transcriptional silencing in the presence of Sir proteins [16182251]. Interventions: Assays: Replicative Lifespan Classification: Aging Relevance Analysis/Source:  GenAge GenDRHomologs Edit \ Update (Admin) | Delete |
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