ATG17

Symbol: ATG17
Name: AuTophaGy related 17
Alias: APG17
Entrez gene ID: 851142
Ensembl gene ID: YLR423C
Species: Yeast (Taxid: 4932)

Functional description:
Atg17p; Scaffold protein responsible for phagophore assembly site organization; regulatory subunit of an autophagy-specific complex that includes Atg1p and Atg13p; stimulates Atg1p kinase activity; human ortholog RB1CC1/FIP200 interacts with p53, which inhi /.../utophagy in human cells [Source:SGD;Acc:S000004415] [Ensembl]; Scaffold protein responsible for phagophore assembly site organization; regulatory subunit of an autophagy-specific complex that includes Atg1p and Atg13p; stimulates Atg1p kinase activity; human ortholog RB1CC1/FIP200 interacts with p53, which inhibits autophagy in human cells [SGD]

Observation:

ATG17 deletion decreases replicative lifespan under AL and blocks DR-lifespan extension. ATG17 mutant's replicative lifespan decreases by 70% on DR [18690010].



Interventions:
  • ATG17 deletion

  • Assays: Replicative Lifespan

    Classification:
  • Aging-Suppressor
  • Negative Aging-Suppressor
  • DR-Essential


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • ATG17 (4932)
  • KLLA0D02750g (28985)
  • AGOS_AER106C (33169)



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