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Symbol: ADH1 Name: Alcohol DeHydrogenase 1 Alias: ADC1 Entrez gene ID: 854068 Ensembl gene ID: YOL086C Species: Yeast (Taxid: 4932) Functional description: Adh1p; Alcohol dehydrogenase, fermentative isozyme active as homo- or heterotetramers; required for the reduction of acetaldehyde to ethanol, the last step in the glycolytic pathway [Source:SGD;Acc:S000005446] [Ensembl] Observation: Deletion of ADH1 increases replicative lifespan by 20% in the alpha strain and 15% in the a strain [18340043]. Adh1 is oxidatively modified during aging and its activity becomes reduced. Overexpression of ADH1 by introducing and extra copy increases mean replicative lifespan by 30% as well as slightly chronological lifespan and was associated with increased Sir2 activity [17975074]. Assays: Classification: Aging Relevance Analysis/Source:  GenAge GenDRHomologs Edit \ Update (Admin) | Delete |
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