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Symbol: cul-5 Entrez gene ID: 179413 Ensembl gene ID: ZK856.1 Species: Worm (Taxid: 6239) Functional description: Probable core component of cullin-based SCF-like E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. In association with rbx-2 seems to be involved in meiotic cell cycle progression in the germline. Required for phosphorylation of the MAP kinase MPK-1 in the germline. [UniProt] Observation: RNAi increased lifespan of WT and glp-1 mutant, but did not affect significantly the lifespan of daf-2 mutant. Assays: Classification: Aging Relevance Analysis/Source:  GenAge GenDRHomologs Edit \ Update (Admin) | Delete |
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