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Symbol: Rbr-2 Entrez gene ID: 177985 Ensembl gene ID: ZK593.4 Species: Worm (Taxid: 6239) Functional description: Histone demethylase that specifically demethylates 'Lys- 4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Involved in larval development and vulva formation. [UniProt] Observation: RNAi decreased lifespan. Assays: Classification: Aging Relevance Analysis/Source:  GenAge GenDRHomologs Edit \ Update (Admin) | Delete |
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