Denigma: Factor

to

Symbol: to
Name: TakeOut
Entrez gene ID: 43036
Ensembl gene ID: FBgn0039298
Species: Fly (Taxid: 7227)

Functional description:
Participates in a novel circadian output pathway that conveys temporal and food status information to feeding-relevant metabolisms and activities. Involved in male courtship behavior. In the brain-associated fat body, transcription is enhanced by the dsx and fru male-specific isoforms and repressed by the dsx female-specific isoform. [UniProt]

Observation:

Overexpression of to in adult neurons, pericerbral or abdonimal fat body increases male and female lifespan. to overexpression in the adult nervous system, head fat body and abdominal fat body results in 25, 20 and 12-18% increase of mean lifespan. On average the mean lifespan is extended for males and females by 18 and 26%, while maximum lifespan of male and female is increased by 13 and 25% [20519778].

Starvation, DR and many longevity mutants (like Rpd3, Sir2, chico, methusalem) all upregulate takeout (to). to is a secreted potential juvenile hormone binding protein and its induction by starvation is blocked by all arrhythmic central clock mutants [20519778; 20622267].

Interventions:

to overexpression +12 to +26% +13 to +25%

Assays: Organismal Lifespan
Mean: +12 to +26
Maximum: +13 to +25

Classification:

Aging-Suppressor

Positive Aging-Suppressor

Type:

Gene

Protein coding

References:

20519778: Comparative transcriptional profiling identifies takeout as a gene that regulates life span.

20622267: Dietary restriction and other lifespan extending pathways converge at the activation of the downstream effector takeout.

Aging Relevance Analysis/Source:

GenAge