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Symbol: zfp-1 Name: Zinc Finger Protein Entrez gene ID: 176237 Ensembl gene ID: F54F2.2 Species: Worm (Taxid: 6239) Functional description: Protein ZFP-1; Uncharacterized protein F54F2.2, isoform a [Source:UniProtKB/Swiss-Prot;Acc:P34447] [Ensembl]; zfp-1 encodes a leucine zipper, zinc finger, and PHD/LAP domain (plant homeodomain/leukemia-associated protein)-containing protein homologous to human AF10 (OMIM:602409, which is involved in chromosomal translocations associated with acute leukemia); loss of zfp-1 activity via RNA-mediated interference (RNAi) results in suppression of RNAi, suggesting that ZFP-1 plays a role in gene silencing; based on sequence similarity, ZFP-1 is predicted to associate with chromatin. [WormBase] Observation: RNA interference shortened lifespan. Assays: Classification: Aging Relevance Analysis/Source:  GenAge GenDRHomologs Edit \ Update (Admin) | Delete |
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