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Symbol: ZDS1 Name: Zillion Different Screens 1 Alias: CES1; CKM1; NRC1; OSS1 Entrez gene ID: 855316 Ensembl gene ID: YMR273C Species: Yeast (Taxid: 4932) Functional description: Zds1p; Protein with a role in regulating Swe1p-dependent polarized growth; interacts with silencing proteins at the telomere; has a role in Bcy1p localization; implicated in mRNA nuclear export; involved in mitotic exit through Cdc14p regulation [Source:SGD;Acc:S000004886] [Ensembl]; Protein with a role in regulating Swe1p-dependent polarized growth; involved in maintaining Cdc55p in the cytoplasm where it promotes mitotic entry; involved in mitotic exit through Cdc14p regulation; interacts with silencing proteins at the telomere; has a role in Bcy1p localization; implicated in mRNA nuclear export [SGD] Observation: Deletion of ZDS1 increases replicative lifespan by 37% in a SIR3-dependent manner [10662670]. Null mutation in ZDS1 causes 100-fold decrease in telomeric silencing, a nine-fold increase in rDNA silencing, reduces rDNA recombination, and decreases Sir3 phosphorylation [10662670]. Interventions: Assays: Replicative Lifespan Classification: Aging Relevance Analysis/Source:  GenAge GenDRHomologs Edit \ Update (Admin) | Delete |
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