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Symbol: YKU80 Name: Subunit of the telomeric Ku complex (Yku70p-Yku80p) Entrez gene ID: 855132 Ensembl gene ID: YMR106C Species: Yeast (Taxid: 4932) Functional description: Yku80p; Subunit of the telomeric Ku complex (Yku70p-Yku80p), involved in telomere length maintenance, structure and telomere position effect; relocates to sites of double-strand cleavage to promote nonhomologous end joining during DSB repair [Source:SGD;Acc:S000004712] [Ensembl] Observation: Deletion of YKU80 significantly shortens replicative lifespan, but does not accelerate the normal aging process [10521401]. YKU80 null mutant is defective for non-homologous end-joining [8754818] and for telomere silincing [9501103; 9635192] Interventions: Assays: Replicative Lifespan Classification: Aging Relevance Analysis/Source:  GenAge GenDRHomologs Edit \ Update (Admin) | Delete |
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