Symbol: XPA Name: Xeroderma pigmentosum, complementation group A Entrez gene ID: 22590 Ensembl gene ID: ENSMUSG00000028329 Species: Mouse (Taxid: 10090) Functional description: Involved in DNA excision repair. Initiates repair by binding to damaged sites with various affinities, depending on the photoproduct and the transcriptional state of the region. Required for UV-induced CHEK1 phosphorylation and the recruitment of CEP164 to cyclobutane pyrimidine dimmers (CPD), sites of DNA damage after UV irradiation (By similarity). [UniProt] Observation: Mutant mice exhibit symptoms of premature ageing, including reduced lifespan, osteoporosis and kyphosis, osteosclerosis, early greying, cachexia, and infertility. Assays: Organismal Lifespan Classification: Aging Relevance Analysis/Source: Homologs Edit \ Update (Admin) | Delete |
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