wwp-1

Symbol: wwp-1
Name: WW domain Protein (E3 ubiquitin ligase) 1
Entrez gene ID: 171647
Ensembl gene ID: Y65B4BR.4
Species: Worm (Taxid: 6239)

Functional description:
Protein WWP-1; WW domain Protein (E3 ubiquitin ligase) family member (wwp-1) [Source:RefSeq peptide;Acc:NP_740775] [Ensembl]

Observation:

RNA interference of wwp-1 decreases median lifespan by 9% in wild-type animals and 24% in daf-2 mutants [18006689]. Loss of wwp-1 function by RNAi or mutation reduces lifespan at 25 degree Celsius, but not 20 degree Celsius. wwp-1 overexpression extends lifespan by up to 20%. Reduced levels of wwp-1 completely suppress the extended longevity of eat-2 mutants. Lifespan of wwp-1 mutants across entire food concentration range by bacterial dilution in liquid culture or on solid plates does not noticeable change. There is no difference in wwp-1 mRNA levels under AL and DR. RNAi reduction of pha-4, but not of daf-16 suppresses increased longevity by wwp-1 overexpression. Mutations in iron sulphur component of complex III, isp-1, increases longevity by reducing mitochondrial function. wwp-1 RNAi does not suppress the extended lifespan of isp-1 mutants and has only minor suppressive effects on lifespan of another mitochondrial mutant, clk-1, and in cyc-1 RNAi treated worms. RNAi depletion of wwp-1 has no effect on long lifespan of daf-2 mutants [19553937].



Interventions:
  • wwp-1 mutation -9%
  • wwp-1 RNAi -9%
  • wwp-1 overexpression +20%

  • Assays: Organismal Lifespan
    Mean: -9

    Classification:
  • Aging-Suppressor
  • Negative Aging-Suppressor
  • Positive Aging-Suppressor
  • DR-Essential


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • WWP1 (9606)
  • WWP1 (9598)
  • WWP1 (9615)
  • WWP1 (9913)
  • Wwp1 (10090)
  • Wwp1 (10116)
  • WWP1 (9031)
  • Su(dx) (7227)
  • AgaP_AGAP009074 (7165)
  • wwp-1 (6239)

  • Orthologs
  • Itch (10116)
  • Su(dx) (7227)
  • WWP2 (9544)
  • LOC707640 (9544)
  • Wwp1 (10116)
  • Itch (10090)
  • Wwp2 (10090)
  • Wwp1 (10090)
  • WWP1 (9544)
  • WWP1 (9606)
  • RSP5 (4932)
  • ITCH (9606)
  • WWP2 (9606)
  • Wwp2 (10116)
  • Itch (10116)
  • Su(dx) (7227)
  • WWP2 (9544)
  • LOC707640 (9544)
  • Wwp1 (10116)
  • Y92H12A.2 (6239)
  • Itch (10090)
  • Wwp2 (10090)
  • Wwp1 (10090)
  • WWP1 (9544)
  • WWP1 (9606)
  • RSP5 (4932)
  • ITCH (9606)
  • WWP2 (9606)
  • Wwp2 (10116)



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