Denigma

W09C5.8

Symbol: W09C5.8
Entrez gene ID: 173237
Ensembl gene ID: W09C5.8
Species: Worm (Taxid: 6239)

Functional description:
Protein W09C5.8; Protein W09C5.8 [Source:UniProtKB/TrEMBL;Acc:Q9U329] [Ensembl]

Observation:

RNAi against W09C5.8 increases mean and maximum lifespan by 62% and 50%, respectively [12447374]. Lifespan extension by RNAi of W09C5.8 is not suppressed by daf-16. Loss of W09C5.8 activity via RNAi can also result in a shortened lifespan, reduced fertility and defects in mitochondrial respiratory chain function [19074434].

W09C5.8 RNAi animals have lower ATP content and oxygen consumption [12447374].



Interventions:
  • W09C5.8 RNAi +62% +50%

    • Assays: Organismal Lifespan

    Classification:
  • Aging-Suppressor
  • Negative Aging-Suppressor
  • Gerontogene
  • Positive Gerontogene


    • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

    • Homologs
  • cox4i2 (7955)
  • CG10664 (7227)
  • AgaP_AGAP008727 (7165)
  • W09C5.8 (6239)

    • Note: RNAi was shown to increase lifespan in one study, while it decreases lifespan in another. Why is this?

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