Symbol: sbds-1 Name: Shwachman-Bodian-Diamond Syndrome protein homolog 1 Entrez gene ID: 175218 Ensembl gene ID: W06E11.4 Species: Worm (Taxid: 6239) Functional description: Required for the assembly of mature ribosomes and ribosome biogenesis. Together with EFTUD1, triggers the GTP- dependent release of ribosome maturation factors from 60S pre- ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly. Required for normal levels of protein synthesis. May play a role in cellular stress resistance. May play a role in cellular response to DNA damage. May play a role in cell proliferation (By similarity). [UniProt] Observation: RNA interference of sbds-1 decreases median lifespan by 24% in daf-2 mutants [18006689]. RNAi knockdown of sbds-1 starting at hatching or only during the adulthood significantly decreases lifespan of eat-2 without affecting wild-type lifespan. SBDS-1 are elevated in eat-2 mutants. Increased content of SBDS-1 is, at least partially, required for lifespan-extension by DR [22810224]. Interventions: Assays: Organismal Lifespan Classification: Aging Relevance Analysis/Source: Homologs Edit \ Update (Admin) | Delete |
Comment on This Data Unit