sbds-1

Symbol: sbds-1
Name: Shwachman-Bodian-Diamond Syndrome protein homolog 1
Entrez gene ID: 175218
Ensembl gene ID: W06E11.4
Species: Worm (Taxid: 6239)

Functional description:
Required for the assembly of mature ribosomes and ribosome biogenesis. Together with EFTUD1, triggers the GTP- dependent release of ribosome maturation factors from 60S pre- ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly. Required for normal levels of protein synthesis. May play a role in cellular stress resistance. May play a role in cellular response to DNA damage. May play a role in cell proliferation (By similarity). [UniProt]

Observation:

RNA interference of sbds-1 decreases median lifespan by 24% in daf-2 mutants [18006689]. RNAi knockdown of sbds-1 starting at hatching or only during the adulthood significantly decreases lifespan of eat-2 without affecting wild-type lifespan. SBDS-1 are elevated in eat-2 mutants. Increased content of SBDS-1 is, at least partially, required for lifespan-extension by DR [22810224].



Interventions:
  • sbds-1 RNAi -24%

  • Assays: Organismal Lifespan

    Classification:
  • Aging Associated
  • DR-Induced
  • DR-Essential
  • No Age Effect


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • SBDS (9606)
  • SBDS (9598)
  • SBDS (9615)
  • SBDS (9913)
  • Sbds (10090)
  • Sbds (10116)
  • SBDS (9031)
  • sbds (7955)
  • CG8549 (7227)
  • AgaP_AGAP007882 (7165)
  • sbds-1 (6239)
  • SPAC4F8.03 (4896)
  • SDO1 (4932)
  • KLLA0F15532g (28985)
  • AGOS_AAL154C (33169)
  • GeneID:2676018 (148305)
  • NCU00476 (5141)
  • AT1G43860 (3702)
  • Os08g0107500 (4530)



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