vrk-1

Symbol: vrk-1
Name: Vaccinia Related Kinase
Entrez gene ID: 174004
Ensembl gene ID: F28B12.3
Species: Worm (Taxid: 6239)

Functional description:
Serine/threonine kinase that phosphorylates baf-1, thus regulating the association of baf-1 with chromatin and nuclear membrane proteins during nuclear envelope formation. May act through the egl-17 signaling pathway. Essential in hermaphrodites for formation of the vulva, uterus, and uterine seam cells and for development and maintenance of the somatic gonad and thus the germ line. Acts to prevent cep-1 from triggering an inappropriate cell cycle arrest, thereby promoting germ cell proliferation. Regulates anchor cell polarity and the timing of anchor cell invasion through the basement membranes separating vulval and somatic gonadal cells during the L3 larval stage. [UniProt]

Observation:

RNA interference decreased median lifespan by 36% in wild type animals, 54% in a daf-2 background and 12% in daf-2/daf-16 double mutants.



Assays:

Classification:

Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • VRK1 (9606)
  • VRK1 (9598)
  • VRK1 (9615)
  • VRK1 (9913)
  • Vrk1 (10090)
  • Vrk1 (10116)
  • VRK1 (9031)
  • LOC794952 (7955)
  • vrk1 (7955)
  • LOC100333110 (7955)
  • LOC100334558 (7955)
  • ball (7227)
  • AgaP_AGAP001933 (7165)
  • vrk-1 (6239)



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