UTH1

Symbol: UTH1
Name: yoUTH 1
Entrez gene ID: 853916
Ensembl gene ID: YKR042W
Species: Yeast (Taxid: 4932)

Functional description:
Uth1p; Mitochondrial outer membrane and cell wall localized SUN family member involved in cell wall biogenesis and required for mitochondrial autophagy; involved in the oxidative stress response, life span during starvation, and cell death [Source:SGD;Acc:S000001750] [Ensembl]

Observation:

Mutation in UTH1 increases replicative lifespan by approximately 15% [7859289].

UTH1 mutant has enhanced stress resistance to cold stress [7859289], heat shock [10870102], starvation [7859289], hydrogen peroxide, but is sensitive to paraquat and oxygen [9799359].



Interventions:
  • UTH1 deletion +15%

  • Assays: Replicative Lifespan

    Classification:
  • Gerontogene
  • Positive Gerontogene


  • References:
  • 7859289: Mutation in the silencing gene SIR4 can delay aging in S. cerevisiae.


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • UTH1 (4932)
  • KLLA0E14939g (28985)
  • AGOS_ADR322W (33169)



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