URE2

Symbol: URE2
Name: UREidosuccinate transport 2
Entrez gene ID: 855492
Ensembl gene ID: YNL229C
Species: Yeast (Taxid: 4932)

Functional description:
Ure2p; Nitrogen catabolite repression transcriptional regulator that acts by inhibition of GLN3 transcription in good nitrogen source; has glutathione peroxidase activity and can mutate to acquire GST activity; altered form creates [URE3] prion [Source:SGD;Acc:S000005173] [Ensembl]

Observation:

Deletion of URE2 increase mean replicative lifespan by 21-31% in BY4742 [16293764]. URE2 deletion increases replicative lifespan increased by 20% in the alpha strain [19030232].



Interventions:
  • URE2 deletion +20 to +31%

  • Assays: Organismal Lifespan

    Classification:
  • Gerontogene
  • Positive Gerontogene


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • gst1 (4896)
  • gst2 (4896)
  • URE2 (4932)
  • KLLA0D19624g (28985)
  • AGOS_ABL195C (33169)
  • GeneID:2680058 (148305)
  • NCU05780 (5141)



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