Denigma

unc-64

Symbol: unc-64
Name: UNCoordinated
Entrez gene ID: 176743
Ensembl gene ID: F56A8.7
Species: Worm (Taxid: 6239)

Functional description:
Plays a critical role in several secretory processes, including cuticle secretion and neurotransmitter release, and probably assists in neuronal membrane maturation or the final stages of neuronal differentiation. Essential for embryonic viability and development. Has a role in dauer formation and adult life span. Required for locomotion. [UniProt]

Observation:

Mutations in unc-64 result in constitutive dauer formation and increase lifespan, which is suppressed by mutations in daf-16 [10377425]. unc-64 mutation increases mean and maximum lifespan [16280150]. unc-64 mutation increased lifespan of hermaphrodites by approximately 70% and those of males by 150% [10377425; 4366476; 10747056].

unc-64 mutants are uncoordinated [4366476].



Interventions:
  • unc-64 mutation +70 to +150%

    • Assays: Organismal Lifespan

    Classification:
  • Gerontogene
  • Positive Gerontogene


    • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

    • Homologs
  • STX1A (9606)
  • STX1A (9598)
  • STX1A (9615)
  • STX1A (9913)
  • Stx1a (10090)
  • Stx1a (10116)
  • STX1A (9031)
  • Syx1A (7227)
  • AgaP_AGAP007698 (7165)
  • unc-64 (6239)
  • psy1 (4896)
  • SSO1 (4932)
  • SSO2 (4932)
  • KLLA0C15961g (28985)
  • AGOS_AFL139W (33169)
  • GeneID:2677682 (148305)
  • NCU11387 (5141)
  • Os03g0787000 (4530)



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