unc-62

Symbol: unc-62
Name: UNCoordinated
Entrez gene ID: 178845
Ensembl gene ID: T28F12.2
Species: Worm (Taxid: 6239)

Functional description:
Acts redundantly with ceh-20 and ceh-40 to perform overlapping roles during embryogenesis. Required for postembryonic development of the ectoderm, including the Q, V and P cell lineages, playing a crucial role in ensuring that these cells and their descendants undergo their invariant patterns of cell division, migration, fusion and morphogenesis. Has a role in the mig-13 pathway to promote anterior migration of neuroblasts in the Q lineage. Required for multiple roles in regulating vulva development. [UniProt]

Observation:

RNA interference in adulthood extended mean lifespan by 38%.



Assays:

Classification:

Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • MEIS1 (9606)
  • MEIS1 (9598)
  • MEIS1 (9615)
  • MEIS1 (9913)
  • Meis1 (10090)
  • Meis1 (10116)
  • meis1 (7955)
  • hth (7227)
  • AgaP_AGAP002178 (7165)
  • unc-62 (6239)



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