Denigma

unc-32

Symbol: unc-32
Name: UNCoordinated
Entrez gene ID: 176257
Ensembl gene ID: ZK637.8
Species: Worm (Taxid: 6239)

Functional description:
Vacuolar H+-ATPase V0 sector, subunit a; Required for assembly and activity of the vacuolar ATPase. Potential role in differential targeting and regulation of the enzyme for a specific organelle (By similarity). [UniProt]

Observation:

unc-32 mutation extends male lifespan by about 170%, but has no effect on hermaphrodite lifespan [10747056].

unc-31 mutants are uncoordinated [4366476].



Interventions:
  • unc-32 mutation +170%

    • Assays: Organismal Lifespan

    Classification:
  • Gerontogene
  • Positive Gerontogene


    • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

    • Homologs
  • ATP6V0A1 (9606)
  • ATP6V0A1 (9598)
  • ATP6V0A1 (9615)
  • ATP6V0A1 (9913)
  • Atp6v0a1 (10090)
  • Atp6v0a1 (10116)
  • ATP6V0A1 (9031)
  • Vha100-1 (7227)
  • AgaP_AGAP003711 (7165)
  • unc-32 (6239)
  • vph1 (4896)
  • VPH1 (4932)
  • KLLA0C07491g (28985)
  • AGOS_ADR177C (33169)
  • GeneID:2677120 (148305)
  • NCU03463 (5141)
  • VHA-A1 (3702)
  • Os01g0834200 (4530)



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