|
Symbol: unc-31 Name: UNCoordinated Entrez gene ID: 178233 Ensembl gene ID: ZK897.1 Species: Worm (Taxid: 6239) Functional description: Protein UNC-31; Calcium-dependent secretion activator [Source:UniProtKB/Swiss-Prot;Acc:Q23658] [Ensembl] Observation: Mutation in unc-31 increases hermaphrodite lifespan by approximately 70% and male lifespan by 150% [10377425; 11063684; 10747056]. unc-31 also cause constitutive dauer formation. Both phenotypes, enhanced longevity and constitutive dauer formation are suppressed by mutations in daf-16. unc-31 site of action is neuronal [10377425]. unc-31 mutants are uncoordinated [4366476] and exhibit dauer constitutive phenotype [10377425], are lethargic, feed constitutively, are defective in egg-laying, and produce dauer larvae that fail to recover [8462849]. Interventions: Assays: Organismal Lifespan Classification: Aging Relevance Analysis/Source:  GenAge GenDRHomologs Edit \ Update (Admin) | Delete |
Comment on This Data Unit