Symbol: age-1 Name: AGEing alteration 1 Alias: AGEing alteration AGE-1, abnormal DAuer Formation DAF-23 Entrez gene ID: 174762 Ensembl gene ID: B0334.8 Species: Worm (Taxid: 6239) Functional description: Phosphatidylinositol 3-kinase homolog that regulates longevity and diapause. Could function in the development or neuroendocrine signaling of the dauer pathway. [UniProt] Observation: Recessive knockout mutants of age-1 have a 40-65% increase in mean lifespan and a 65-110% increase in maximum lifespan [8608934; 8700226]. age-1(mg44) zygotic null mutants have a mean (99%) and maximum (117%) lifespan extension [18828672]. Even in axenic culture lifespan of age-1 is extended up to 100%. age-1 mutation significantly extends lifespan under AL, but only slightly under sDR [16720740]. RNAi against age-1 extends lifespan by 30% [8700226; 8608934]. age-1 RNAi increases mean and maximum lifespan by 36-46% and 48-50% [12447374]. RNAi against age-1 increases mean lifespan by 83% [18828672]. age-1 mutants are dauer constitutive [8056303] and display lower brood size as well as increased embryonic lethality [9504918]. Additionally, age-1 mutants have elevated levels of superoxidase dismutase and catalase activities [8389142]. age-1 RNAi and mutation extend lifespan by 30% and 100%, respectively [8700226; 8608934]. Interventions: Assays: Organismal Lifespan Mean: +40 to +99 Maximum: +65 to +117 Classification: Aging Relevance Analysis/Source: Homologs Orthologs Edit \ Update (Admin) | Delete |
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