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Symbol: Ucp2 Name: uncoupling protein 2 (mitochondrial, proton carrier) Entrez gene ID: 22228 Ensembl gene ID: ENSMUSG00000033685 Species: Mouse (Taxid: 10090) Functional description: UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation from ATP synthesis. As a result, energy is dissipated in the form of heat (By similarity). [UniProt] Observation: Overexpression in hypocretin neurons results in mice with elevated hypothalamic temperature and reduction of core body temperature and a 12% increase in median lifespan in males and 20% increase in females. Assays: Organismal Lifespan Classification: Aging Relevance Analysis/Source:  GenAge GenDRHomologs Edit \ Update (Admin) | Delete |
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