vps-22

Symbol: vps-22
Name: related to yeast Vacuolar Protein Sorting factor 22
Entrez gene ID: 175672
Ensembl gene ID: C27F2.5
Species: Worm (Taxid: 6239)

Functional description:
Protein VPS-22; Protein VPS-22 [Source:UniProtKB/TrEMBL;Acc:Q18258] [Ensembl]; C27F2.5 encodes the C. elegans ortholog of the conserved vacuolar protein sorting protein EAP30/SNF8/VPS22; by homology, the product of C27F2.5 is predicted to be a component of an ESCRT-II complex (Endosomal Sorting Complex Required for Transport) that functions in endosomal transport. [WormBase]

Observation:

RNA interference of vps-22 decreases median lifespan by 43% in wild type animals, 33% in a daf-2 background and 9% in daf-2/daf-16 double mutants [18006689].



Interventions:
  • vps-22 RNAi -43%

  • Assays: Organismal Lifespan

    Classification:
  • Aging-Suppressor
  • Negative Aging-Suppressor


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • SNF8 (9606)
  • SNF8 (9615)
  • SNF8 (9913)
  • Snf8 (10090)
  • Snf8 (10116)
  • SNF8 (9031)
  • snf8 (7955)
  • snf8 (7955)
  • lsn (7227)
  • AgaP_AGAP000771 (7165)
  • C27F2.5 (6239)
  • dot2 (4896)
  • SNF8 (4932)
  • KLLA0E14323g (28985)
  • AGOS_AGL002C (33169)
  • GeneID:2675375 (148305)
  • NCU07843 (5141)
  • VPS22 (3702)
  • Os09g0529700 (4530)



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