TOR1

Symbol: TOR1
Name: Target Of Rapamycin 1
Alias: DRR1
Entrez gene ID: 853529
Ensembl gene ID: YJR066W
Species: Yeast (Taxid: 4932)

Functional description:
Tor1p; PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that controls growth in response to nutrients by regulating translation, transcription, ribosome biogenesis, nutrient transport and autophagy; involved in meiosis [Source:SGD;Acc:S000003827] [Ensembl]

Observation:

TOR1 deletion extends mean and maximum replicative lifespan by 21 and 25% [16293764] as well as chronological lifespan [21076178]. This lifespan extension is independent of SIR2 and additive with deletion of FOB1 [16293764]. Deletion of TOR1 fails to increase the replicative lifespan of a sir2 mutant [20947565]. Deletion of TOR1 substantially extends chronological lifespan, increasing median survival almost 3-fold (wild-type 4.5 days, tor1 null 12 days), i.e. by 167%. By 21 days in culture, the vast majority of wild-type cells had died (>99.9%), whereas many tor1 null cells remained viable. Deletion of TOR1 also extends the chronological lifespan of the relatively short-lived BY4742 strain, one of the two haploid genetic backgrounds of the widely used Yeast Knockout Collection available from Open Biosystems. Deletion of TOR1 fails to extend chronological lifespan in Petite strains that are unable to respire [17403371]. TOR1 deletion increases replicative lifespan by 30% in the alpha strain and 20% in a strain [19030232]. TOR1 deletion mutant have and increased mean and maximum replicative lifespan by 21% and 6%, respectively [21931558]. Deletion of TOR1 extends replicative lifespan as well as chronological lifespan [21076178] and glucose restriction fails to further extend the long replicative lifespan of tor1Delta [16293764; 16418483; 18225956]. Water starvation (extreme DR) further extends chronological lifespan of tor1 mutants [18225956].



Interventions:
  • TOR1 Deletion +21 to +30% +167% +6 to +25%

  • Assays: Replicative Lifespan Chronological Lifespan
    Mean: +21 to +30
    Median: +167
    Maximum: +6 to +25

    Classification:
  • Gerontogene
  • Positive Gerontogene
  • DR-Essential


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • tor2 (4896)
  • TOR1 (4932)
  • GeneID:5051531 (148305)
  • NCU05608 (5141)

  • Orthologs
  • tor2 (4896)
  • let-363 (6239)
  • let-363 (6239)
  • tor2 (4896)
  • let-363 (6239)
  • let-363 (6239)
  • tor2 (4896)
  • let-363 (6239)



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