tax-6

Symbol: tax-6
Name: abnormal CHEmotaxis 6
Entrez gene ID: 177943
Ensembl gene ID: C02F4.2
Species: Worm (Taxid: 6239)

Functional description:
Protein TAX-6; abnormal CHEmotaxis family member (tax-6) [Source:RefSeq peptide;Acc:NP_001021292] [Ensembl]; tax-6 encodes an ortholog of calcineurin A that is required for inhibition and adaptation of several sensory neurons and for the normal regulation of egg-laying by serotonin; TAX-6 stimulates transcription of rcn-1, and binds RCN-1 protein if free Ca[2+] is present; in general, calcineurin positively regulates calcium-dependent signaling; tax-6 loss-of-function mutants exhibit an extended lifespan which is characterized by enhanced autophagy and dependent upon the presence of functional bec-1. [WormBase]

Observation:

Post-developmental RNA interference of tax-6 increases mean lifespan by 27% [17673661]. tax-6 RNAi extends lifespan [21331044].



Interventions:
  • tax-6 RNAi +27%

  • Assays: Organismal Lifespan

    Classification:
  • Gerontogene
  • Positive Gerontogene


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • PPP3CA (9606)
  • PPP3CA (9598)
  • PPP3CA (9615)
  • PPP3CA (9913)
  • Ppp3ca (10090)
  • Ppp3ca (10116)
  • ppp3ca (7955)
  • ppp3cb (7955)
  • CanA-14F (7227)
  • Pp2B-14D (7227)
  • AgaP_AGAP001279 (7165)
  • tax-6 (6239)
  • ppb1 (4896)
  • CNA1 (4932)
  • KLLA0B05489g (28985)
  • AGOS_AER118C (33169)
  • GeneID:2683376 (148305)
  • NCU03804 (5141)
  • PF08_0129 (5833)



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