Denigma: Factor

spt-4

Symbol: spt-4
Name: SPT transcription factor family
Entrez gene ID: 175172
Ensembl gene ID: F54C4.2
Species: Worm (Taxid: 6239)

Functional description:
May function as a component of the DRB sensitivity- inducing factor complex (DSIF complex), which regulates transcription elongation by RNA polymerase II. DSIF may enhance transcriptional pausing at sites proximal to the promoter, which may in turn facilitate the assembly of an elongation competent RNA polymerase II complex. [UniProt]

Observation:

RNAi of spt-4 starting at L1 extends mean, 75%ile and median lifespan by 4, 8 and 8% [15998808].

Interventions:

spt-4 RNAi +4% +8%

Assays: Organismal Lifespan

Classification:

Gerontogene

Positive Gerontogene

Aging Relevance Analysis/Source:

GenAge