SOD1

Symbol: SOD1
Name: SuperOxide Dismutase 1
Alias: CRS4
Entrez gene ID: 853568
Ensembl gene ID: YJR104C
Species: Yeast (Taxid: 4932)

Functional description:
Sod1p; Cytosolic copper-zinc superoxide dismutase; some mutations are analogous to those that cause ALS (amyotrophic lateral sclerosis) in humans [Source:SGD;Acc:S000003865] [Ensembl]

Observation:

The overexpression of Sods, mitochondrial Sod2 and cytosolic CuZnSod (Sod1), in combination delays the age-dependent reversible inactivation of mitochondrial aconitase, a superoxide-sensitive enzyme, and extends chronological lifespan by 30% [12586694]. Deletion of SOD1 decreases replicative lifespan by 40% [17460215]. Overexpression of SOD1 with CCS1 levuates the level of Cn, Zn-Sod activity and increased chronological lifespan. However overexpression of SOD1 without high cooper or simultonous overexpression of CCS1 shortened both chronological and replicative lifespan [15659212]. Overexpression of SOD1 has no effect on replicative lifespan [10224252]. Deletion of SOD1 shortens replicative lifespan by approximately 40%. The magnitude of the decrease in lifespan does not appear to dependent on oxygen concentration in the atmosphere [12020810]. Deletion of SOD1 shortens replicative lifespan [10547026]. Deletion of SOD1 shortens replicative as well as chronological lifespan [10222047].

Cells with a deletion of SOD1 exhibit a profound defect in entry into and survival during stationary phase (i.e. chronological lifespan) in the W303-B strain [8647826; 10222047], which is partially suppressed by expression of human Bcl-2 [9199172].

Hypersensitivity to oxygene and significantly decreased replicative lifespan of SOD1 deletion can be ameliorated by exogenous ascorbate. If acorbate's negative effects of auto-oxidation are prevented by exchange of medium, ascorbate prolongs mean and maximum replicative lifespan in the atmosphere of air and pure oxygene [15621721].

SOD1 deletion causes sensitivity to hyperoxia as well as methionine and lysine auxotrohies [9199172].



Interventions:
  • SOD1 overexpression
  • SOD1 deletion -40%

  • Assays: Replicative Lifespan Chronological Lifespan

    Classification:
  • Aging Associated
  • Aging-Suppressor
  • Negative Aging-Suppressor
  • Positive Aging-Suppressor


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • SOD1 (9606)
  • SOD1 (9598)
  • SOD1 (9615)
  • SOD1 (9913)
  • SOD1 (9913)
  • Sod1 (10090)
  • Gm8566 (10090)
  • Sod1 (10116)
  • SOD1 (9031)
  • sod1 (7955)
  • Sod (7227)
  • SOD3 (7165)
  • sod-5 (6239)
  • sod-1 (6239)
  • sod1 (4896)
  • SOD1 (4932)
  • KLLA0E05567g (28985)
  • AGOS_AGL321W (33169)
  • GeneID:2682824 (148305)
  • NCU02133 (5141)
  • CSD1 (3702)
  • Os03g0351500 (4530)
  • Os07g0665200 (4530)

  • Note: SOD1 is only Positive Aging-Suppressor Gene in combination with SOD2 oveexpression. Changed Gene Symbols to capital letters.

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