smk-1

Symbol: smk-1
Name: SMEK (Dictyostelium Suppressor of MEK null) homolog 1
Entrez gene ID: 179243
Ensembl gene ID: F41E6.4
Species: Worm (Taxid: 6239)

Functional description:
Protein SMK-1; SMEK (Dictyostelium Suppressor of MEK null) homolog family member (smk-1) [Source:RefSeq peptide;Acc:NP_001023909] [Ensembl]; smk-1 encodes a novel, evolutionarily conserved protein that is orthologous to the mammalian and Dictyostelium discoideum SMEK (suppressor of MEK null) proteins; smk-1 activity is essential for several aspects of DAF-16-mediated longevity namely, the defense response to pathogenic bacteria and increased resistance to oxidative and UV-induced damage; in regulating DAF-16 activity, SMK-1 appears to act by affecting the transcription of DAF-16 target genes, such as sod-3, ctl-1, and lys-8; SMK-1 is present in the nucleus of intestinal cells, many head and tail neurons, and some hypodermal cells throughout development. [WormBase]

Observation:

RNA interference of smk-1 completely suppresses the extended longevity of daf-2 mutations and partly the life-extension of clk-1 mutants. smk-1 RNAi decreases mean and maximum lifespan of similar level than daf-16 knockdown [16530049]. smk-1 RNAi only slightly shortens the lifespan of wild-type worms, but abolishes the extended lifespan of eat-2 mutants [17476212]. Loss of smk-1 by temperature sensitive allele suppresses the extended lifespan under optimal bDR, but not the response to DR itself [17476212].



Interventions:
  • smk-1 RNAi
  • smk-1 mutation
  • smk-1 mutation

  • Assays: Organismal Lifespan

    Classification:
  • DR-Essential


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • SMEK1 (9606)
  • LOC739423 (9598)
  • SMEK1 (9598)
  • SMEK1 (9615)
  • SMEK1 (9913)
  • Smek1 (10090)
  • Smek1 (10116)
  • SMEK1 (9031)
  • smek1 (7955)
  • flfl (7227)
  • AgaP_AGAP003402 (7165)
  • smk-1 (6239)
  • AT3G06670 (3702)
  • Os01g0337600 (4530)

  • Orthologs
  • 4932429P05Rik (10090)
  • 4930415L06Rik (10090)
  • SMEK2 (9544)
  • Smek1 (10116)
  • Smek2 (10116)
  • Smek3 (10116)
  • flfl (7227)
  • LOC701718 (9544)
  • SMEK2 (9606)
  • RGD1563554 (10116)
  • PSY2 (4932)
  • RGD1563978 (10116)
  • RGD1562980 (10116)
  • SMEK1 (9606)
  • Smek2 (10090)
  • Smek1 (10090)
  • 4932429P05Rik (10090)
  • 4930415L06Rik (10090)
  • SMEK2 (9544)
  • Smek1 (10116)
  • Smek2 (10116)
  • Smek3 (10116)
  • flfl (7227)
  • LOC701718 (9544)
  • SMEK2 (9606)
  • RGD1563554 (10116)
  • PSY2 (4932)
  • RGD1563978 (10116)
  • RGD1562980 (10116)
  • SMEK1 (9606)
  • Smek2 (10090)
  • Smek1 (10090)

  • Note: It only slightly shortens the lifespan of wild-type worms?

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